{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:22:43Z","timestamp":1781608963928,"version":"3.54.5"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T00:00:00Z","timestamp":1277856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations.<\/jats:p>\n                  <jats:p>Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 5' nuclease assay.<\/jats:p>\n                  <jats:p>\n                    Results: Rs3135388*A was positively associated with multiple sclerosis (OR = 3.93; 95% CI = 2.58\u20145.97, p = 1.18 \u00d7 10\n                    <jats:sup>-09<\/jats:sup>\n                    ) but negatively associated with NMO (OR = 0.57; 95% CI = 0.36\u20140.91, p = 0.01).\n                  <\/jats:p>\n                  <jats:p>Conclusions: Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501.<\/jats:p>","DOI":"10.1177\/1352458510374340","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T21:35:22Z","timestamp":1277933722000},"page":"981-984","source":"Crossref","is-referenced-by-count":22,"title":["HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica"],"prefix":"10.1177","volume":"16","author":[{"given":"Marcelo","family":"Matiello","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Schaefer-Klein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doralina G","family":"Brum","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun H","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G","family":"Weinshenker","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester MN, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"the NMO genetics collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,6,30]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1086\/367781"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.69"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn353"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.9.1689"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01172.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508102085"},{"key":"atypb7","first-page":"226","volume":"66","author":"Cree BA","year":"2009","journal-title":"Arch Neurol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509350741"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509355067"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1038\/ng1885"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01101.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.742"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1191\/135248506ms1252oa"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000289761.64862.ce"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.06.085"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458510374340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458510374340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:28:43Z","timestamp":1777692523000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458510374340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,30]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1177\/1352458510374340"],"URL":"https:\/\/doi.org\/10.1177\/1352458510374340","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,30]]}}}