{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:12:50Z","timestamp":1777936370819,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T00:00:00Z","timestamp":1280880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Background: The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system. It is well documented that amount of IL-6 is increased in serum, cerebrospinal fluid and central nervous system lesions of patients with multiple sclerosis. A single nucleotide polymorphism at position -174 in the IL-6 gene promotor appears to influence IL-6 expression. Recently, several researchers have focused on HLA-DRB alleles, specifically HLA-DRB1*1501, as a potential risk allele in the pathogenesis of multiple sclerosis.<\/jats:p>\n                  <jats:p>Objective: To investigate the possible influence of IL-6\/-174 polymorphisms on susceptibility to multiple sclerosis and its integration with HLA-DRB1*1501. Genomic DNA was extracted from whole blood of 345 patients with multiple sclerosis and 426 control subjects.<\/jats:p>\n                  <jats:p>Method: The SSP-PCR method was used to determine genotypes and Fisher\u2019s exact test was applied to determine differences between groups. HLA-DRB1*1501 was observed more frequently among multiple sclerosis patients compared with healthy subjects (45% and 34%, respectively; OR = 1.6, 95% CI = 1.2\u20142.2, p = 0.0018). At the IL-6\/-174 position, the G allele had higher frequency among multiple sclerosis patients compared with controls (77% and 70%, respectively; OR = 1.4, 95% CI = 1.1\u20141.8, p = 0.0038). This difference was more significant among HLA-DRB1*1501-positive patients and controls (81% and 67%, respectively; OR = 1.9, 95% CI = 1.5\u20142.5, p &lt; 0.0001).<\/jats:p>\n                  <jats:p>Results: Our results have shown that the G allele at the IL-6\/-174 promoter polymorphism may be associated with development of multiple sclerosis in this population, and may be strengthened by HLA-DRB1*1501.<\/jats:p>\n                  <jats:p>Conclusions: We suggest more studies to confirm these results in other populations.<\/jats:p>","DOI":"10.1177\/1352458510376177","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T21:47:53Z","timestamp":1280958473000},"page":"1173-1177","source":"Crossref","is-referenced-by-count":16,"title":["<i>HLA-DRB1*1501<\/i>\n                    intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population"],"prefix":"10.1177","volume":"16","author":[{"given":"M.","family":"Shahbazi","sequence":"first","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Molecular Medicine and Genetics, Golestan University of Medical Sciences, Gorgan, Iran,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ebadi","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Neurology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fathi","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Neurology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Roshandel","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Genetics and Immunology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mohamadhosseni","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Genetics and Immunology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tahmasebi","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Genetics and Immunology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center, Genetics and Immunology, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zamani","sequence":"additional","affiliation":[{"name":"Neurogenetics Division, 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