{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:13:07Z","timestamp":1777936387694,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T00:00:00Z","timestamp":1283904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Background: Natalizumab is associated with the potentially life-threatening side-effect progressive multifocal leukoencephalopathy (PML). Little is known about patients\u2019 and physicians\u2019 risk estimates and attitudes towards natalizumab treatment.<\/jats:p>\n                  <jats:p>Methods: Consecutive natalizumab-treated patients ( n = 69) and neurologists ( n = 66) in two centres and cooperating private practices received an evidence-based three-page information leaflet about natalizumab-associated PML and an evaluation sheet.<\/jats:p>\n                  <jats:p>Results: After reading the information, patients were significantly more likely than physicians to intend continuation of natalizumab treatment and willing to accept higher risks of PML: 49% of physicians would stop treatment at a PML risk of 2 : 10,000 or lower, while only 17% of patients would do so ( p &lt; 0.001). This difference could not be explained by risk calculation abilities or lack of understanding. Both groups overestimated natalizumab treatment effects.<\/jats:p>\n                  <jats:p>Conclusion: Patients had a significantly worse perception of multiple sclerosis as a malignant disease. We conclude that patients were willing to accept a higher risk of PML than neurologists. Coherent with their perception of risks and benefits, patients were also more willing to continue treatment. Open information about treatment-related risks is appreciated and might support shared decision making.<\/jats:p>","DOI":"10.1177\/1352458510379819","type":"journal-article","created":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T20:59:35Z","timestamp":1284152375000},"page":"1507-1512","source":"Crossref","is-referenced-by-count":69,"title":["Risk perception in natalizumab-treated multiple sclerosis patients and their neurologists"],"prefix":"10.1177","volume":"16","author":[{"given":"Christoph","family":"Heesen","sequence":"first","affiliation":[{"name":"Institute of Neuroimmunology and Clinical MS Research (INiMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Kleiter","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Clinical MS Research (INiMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Sch\u00e4ffler","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Clinical MS Research (INiMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Kasper","sequence":"additional","affiliation":[{"name":"Department of Dental Prothetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"K\u00f6pke","sequence":"additional","affiliation":[{"name":"Unit of Health Science and Education, University of Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Gaissmaier","sequence":"additional","affiliation":[{"name":"Harding Center for Risk Literacy, Max Planck Institute for Human Development, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,9,8]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12512-3"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38771.583796.7C"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.074"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7094.1580"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00086.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2005.06.002"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.26.3.716"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044396"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.080708.082655"},{"key":"atypb11","volume-title":"PML 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