{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:34:35Z","timestamp":1790886875551,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Background:Despite similarities, neuromyelitis optica (NMO) can be distinguished from multiple sclerosis (MS) by clinical, radiological and serological findings.<\/jats:p>\n                  <jats:p>Objective:This case-control study aimed to determine whether patients with NMO or with MS in an Afro-Caribbean population originating from French West Indies shared the same or different HLA class I and II pattern distribution.<\/jats:p>\n                  <jats:p>Methods:The association with HLA class II (DRB1 and DQB1) alleles was tested in 42 NMO patients, 163 MS patients and 150 healthy controls. HLA-DRB1 and DQB1 typing was undertaken on genomic DNA extracted from peripheral blood leucocytes.<\/jats:p>\n                  <jats:p>Results:By comparison with healthy controls, significantly increased frequency of HLA-DRB1*03 (26.2% vs. 13%, odds ratio 2.4, 95% confidence interval 1.31\u20134.28, p after correction, cp 0.045) was observed in patients with NMO. By contrast, in MS patients, HLA-DRB1*15 (24.8% vs. 13%, odds ratio 2.21, 95% CI 1.45\u20133.36, cp\u2009&lt;\u20090.0015), but not DRB1*03 allele, was positively associated with the disease. Moreover, a modest protective effect of HLA-DRB1*11 in the MS group, independently of DRB1*15 association, was found (13.7% vs. 7% in controls, odds ratio 0.48, p 0.006), but did not survive Bonferroni correction.<\/jats:p>\n                  <jats:p>Conclusion:In conclusion, comparison of the HLA-DRB1 and DQB1 distribution in NMO and MS in this Afro-Caribbean population shows important differences in the HLA associations among NMO and MS.<\/jats:p>","DOI":"10.1177\/1352458510382810","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:18:54Z","timestamp":1285201134000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population"],"prefix":"10.1177","volume":"17","author":[{"given":"R","family":"Deschamps","sequence":"first","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Paturel","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Jeannin","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chausson","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Olindo","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"B\u00e9ra","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bellance","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Smadja","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"C\u00e9saire","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, Martinique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Cabre","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Carib\u00e9en des Maladies Rares Neurologiques et Neuro-Musculaires, CHU de Fort de France, Fort de France, 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