{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:27:10Z","timestamp":1790857630094,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T00:00:00Z","timestamp":1294963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Background: Neuromyelitis optica (NMO) frequently begins with a monofocal episode of optic neuritis or myelitis. A concept named high-risk syndrome (HRS) for NMO has been proposed for patients with monofocal episodes and NMO-IgG antibodies.<\/jats:p>\n                  <jats:p>Objective: To describe HRS patients and compare them with NMO patients.<\/jats:p>\n                  <jats:p>Methods: We identified 30 patients with HRS: 18 with extensive myelitis (HRM) and 12 with optic neuritis (HRON), in a database pooling patients from 25 centres in France. Clinical, laboratory\/magnetic resonance imaging (MRI) data and outcome were analysed and compared with a national cohort of 125 NMO patients extracted from the same database.<\/jats:p>\n                  <jats:p>Results: Mean follow-up was 4.8 years. Mean age at onset was 42.8 years (range: 12.4\u201370) with a female:male ratio of 0.9. Asymptomatic lesions were report on visual evoked potentials in 4\/8 tested HRM patients and on spinal cord MRI in 2\/7 HRON patients. Three patients died, two owing to a cervical lesion. HRS and NMO patients had similar clinical\/paraclinical data, except for a predominance of men in the HRS group and a later mean age at onset in the HRM subgroup.<\/jats:p>\n                  <jats:p>Conclusion: The description of HRS patients is compatible with a monofocal form of NMO. Asymptomatic lesions could be included in a new set of NMO diagnostic criteria.<\/jats:p>","DOI":"10.1177\/1352458510396923","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T20:26:41Z","timestamp":1295036801000},"page":"720-724","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["High-risk syndrome for neuromyelitis optica: a descriptive and comparative study"],"prefix":"10.1177","volume":"17","author":[{"given":"N","family":"Collongues","sequence":"first","affiliation":[{"name":"Strasbourg University Hospital, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Marignier","sequence":"additional","affiliation":[{"name":"Lyon University Hospital, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Z\u00e9phir","sequence":"additional","affiliation":[{"name":"Lille University Hospital, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Blanc","sequence":"additional","affiliation":[{"name":"Strasbourg University Hospital, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Lyon University Hospital, Lyon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Outteryck","sequence":"additional","affiliation":[{"name":"Lille University Hospital, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fleury","sequence":"additional","affiliation":[{"name":"Strasbourg University Hospital, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ruet","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Borgel","sequence":"additional","affiliation":[{"name":"Grenoble University Hospital, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Thouvenot","sequence":"additional","affiliation":[{"name":"Montpellier University Hospital, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Moreau","sequence":"additional","affiliation":[{"name":"Dijon University Hospital, Dijon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Defer","sequence":"additional","affiliation":[{"name":"Caen University Hospital, Caen, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Derache","sequence":"additional","affiliation":[{"name":"Caen University Hospital, Caen, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Marseille University Hospital, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Audoin","sequence":"additional","affiliation":[{"name":"Marseille University Hospital, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Debouverie","sequence":"additional","affiliation":[{"name":"Nancy University Hospital, Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Labauge","sequence":"additional","affiliation":[{"name":"N\u00eemes University Hospital, N\u00eemes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Gout","sequence":"additional","affiliation":[{"name":"Rothschild Foundation Hospital, Paris, 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de","family":"Seze","sequence":"additional","affiliation":[{"name":"Strasbourg University Hospital, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,14]]},"reference":[{"key":"bibr1-1352458510396923","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"bibr2-1352458510396923","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr3-1352458510396923","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"bibr4-1352458510396923","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d31e35"},{"key":"bibr5-1352458510396923","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507084595"},{"key":"bibr6-1352458510396923","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.080390"},{"key":"bibr7-1352458510396923","first-page":"99","volume":"15","author":"Waters P","year":"2008","journal-title":"Int MS 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