{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:53:53Z","timestamp":1789422833507,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T00:00:00Z","timestamp":1297036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Objective: The objective of this research was to study the effect of optic neuritis (ON) on axonal damage in multiple sclerosis (MS) patients. Specifically, we compared changes over 2 years in the retinal nerve fibre layer (RNFL) between affected and contralateral eyes in MS patients with a prior history of ON.<\/jats:p>\n                  <jats:p>Methods: Thirty-four patients with one unilateral definitive episode of ON were included and underwent a complete ophthalmic examination, optical coherence tomography (OCT), scanning laser polarimetry, visual evoked potentials (VEP) and pattern electroretinogram (pERG). All patients were re-evaluated at 12 and 24 months. Parameters were compared between ON-affected and contralateral eyes in an initial exploration and over the course of the follow-up. Correlations between parameter changes were analysed.<\/jats:p>\n                  <jats:p>Results: RNFL thickness and functional parameters showed more affection in ON eyes ( p\u2009\u2264\u20090.05), but changes in measurements during the study were similar between both groups of eyes.<\/jats:p>\n                  <jats:p>Conclusions: Progressive axonal loss can be detected in the optic nerve, but ON is not a risk factor for increased chronic damage in MS patients without ophthalmic relapses. Loss of the RNFL is caused by progressive degeneration associated with the disease.<\/jats:p>","DOI":"10.1177\/1352458510397414","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:14:16Z","timestamp":1297124056000},"page":"830-837","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Effect of optic neuritis on progressive axonal damage in multiple sclerosis patients"],"prefix":"10.1177","volume":"17","author":[{"given":"E","family":"Garcia-Martin","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain."},{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Pueyo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain."},{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JR","family":"Ara","sequence":"additional","affiliation":[{"name":"Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Almarcegui","sequence":"additional","affiliation":[{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."},{"name":"Neurophysiology Department, Miguel Servet University Hospital, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Martin","sequence":"additional","affiliation":[{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."},{"name":"Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pablo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain."},{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Dolz","sequence":"additional","affiliation":[{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."},{"name":"Neurophysiology Department, Miguel Servet University Hospital, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Sancho","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FJ","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain."},{"name":"Instituto Aragones de Ciencias de la Salud (IACS), Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"key":"bibr1-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e3181dbfeac"},{"key":"bibr2-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.05.024"},{"key":"bibr3-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510371640"},{"key":"bibr4-1352458510397414","first-page":"1007","volume":"4","author":"Khanifar AA","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"bibr5-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2009.12.001"},{"key":"bibr6-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70168-X"},{"key":"bibr7-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"bibr8-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1177\/112067211002000123"},{"key":"bibr9-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260612.51849.ed"},{"key":"bibr10-1352458510397414","doi-asserted-by":"crossref","unstructured":"Kallenbach K, Sander B, Tsakiri A, Wanscher B, Fugl\u00f8 D, Larsen M, et al. Neither retinal nor brain atrophy can be shown in patients with isolated unilateral optic neuritis at the time of presentation.\n                      Mult Scler\n                      . 2010; 17 (1): 89\u201395.","DOI":"10.1177\/1352458510382017"},{"key":"bibr11-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.04.010"},{"key":"bibr12-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2010.03.024"},{"key":"bibr13-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22005"},{"key":"bibr14-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"bibr15-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1159\/000099299"},{"key":"bibr16-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-007-9053-1"},{"key":"bibr17-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.1.25"},{"key":"bibr18-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1002\/ana.96"},{"key":"bibr19-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"bibr20-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244490.07925.8b"},{"key":"bibr21-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.924"},{"key":"bibr22-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.10.020"},{"key":"bibr23-1352458510397414","doi-asserted-by":"crossref","unstructured":"Garcia-Martin E, Pinilla I, Idoipe M, Fuertes I and Pueyo V. Intra and interoperator reproducibility of retinal nerve fiber and macular thickness measurements using Cirrus Fourier-domain OCT.\n                      Acta Ophthalmol\n                      . 2010 Nov 25. doi: 10.1111\/j.1755-3768.2010.02045.x. [Epub ahead of print].","DOI":"10.1111\/j.1755-3768.2010.02045.x"},{"key":"bibr24-1352458510397414","doi-asserted-by":"crossref","unstructured":"Klistorner A, Arvind H, Garrick R, Graham S, Paine M and Yiannikas C. Correlation of optical coherence tomography and multifocal visual-evoked potential after optic neuritis.\n                      Invest Ophthalmol Vis Sci\n                      2009 (in press).","DOI":"10.1167\/iovs.09-4577"},{"key":"bibr25-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00724.x"},{"key":"bibr26-1352458510397414","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181aaea32"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458510397414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458510397414","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458510397414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:30:17Z","timestamp":1777692617000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458510397414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1177\/1352458510397414"],"URL":"https:\/\/doi.org\/10.1177\/1352458510397414","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,7]]}}}