{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:44:43Z","timestamp":1791805483872,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T00:00:00Z","timestamp":1310601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>Background: Compared with quantitative observations, the search for qualitative changes that may characterize the immune response to Epstein\u2013Barr virus (EBV) in multiple sclerosis (MS) has been less intense.<\/jats:p>\n                  <jats:p>Objective: To examine the B-cell epitopes of antibodies against the Epstein\u2013Barr nuclear antigen-1 (EBNA-1) and their relevance for MS, through a study in disease-discordant identical twins.<\/jats:p>\n                  <jats:p>Methods: We evaluated the antibodies to all unique, maximally overlapping octapeptides of EBNA-1 in 12 pairs of monozygotic (MZ) twins (9\u2009MS-discordant, 3 healthy), 3 non-twin patients and 2 healthy subjects. All except one of the patients were untreated. The EBV serology of these individuals had been assessed in advance using commercially available and in-house enzyme-linked immunosorbent assay (ELISA) kits, including assays for antibodies against select peptides of EBNA-1: EBNA-72 (GAGGGAGAGG) and EBNA-206 (EADYFEYHQEGGPDGE).<\/jats:p>\n                  <jats:p>Results: The glycine\u2013alanine rich domain of EBNA-1 was immunodominant in all subjects. Compared with healthy individuals, and similarly to what has been described in infectious mononucleosis (IM) patients, affected co-twins and non-twin patients had a significantly increased response to another EBNA-1 epitope (aa. 401\u2013411).<\/jats:p>\n                  <jats:p>Conclusion: In a study that controls for confounders, our data focus an EBNA-1 specificity that may be associated with MS pathogenesis.<\/jats:p>","DOI":"10.1177\/1352458511410515","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T22:25:15Z","timestamp":1310682315000},"page":"1290-1294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Epstein\u2013Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twins"],"prefix":"10.1177","volume":"17","author":[{"given":"R","family":"Mechelli","sequence":"first","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Vittori","sequence":"additional","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Coarelli","sequence":"additional","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Annibali","sequence":"additional","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Cannoni","sequence":"additional","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Aloisi","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Istituto Superiore di Sanit\u00e0, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Salvetti","sequence":"additional","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JA","family":"James","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ristori","sequence":"additional","affiliation":[{"name":"Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,7,14]]},"reference":[{"key":"bibr1-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp312"},{"key":"bibr2-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dabfb5"},{"key":"bibr3-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.08.004"},{"key":"bibr4-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.06.007"},{"key":"bibr5-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad57e"},{"key":"bibr6-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1038\/nature08990"},{"key":"bibr7-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20683"},{"key":"bibr8-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10385"},{"key":"bibr9-1352458511410515","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.4049\/jimmunol.156.10.4018","volume":"156","author":"James JA","year":"1996","journal-title":"J Immunol"},{"key":"bibr10-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1002\/art.21682"},{"key":"bibr11-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510380090"},{"key":"bibr12-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1026"},{"key":"bibr13-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1038\/375798a0"},{"key":"bibr14-1352458511410515","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4049\/jimmunol.162.1.129","volume":"162","author":"Van Sechel AC","year":"1999","journal-title":"J Immunol"},{"key":"bibr15-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.1.48"},{"key":"bibr16-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141553"},{"key":"bibr17-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326576.91097.87"},{"key":"bibr18-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb07320.x"},{"key":"bibr19-1352458511410515","first-page":"141","volume":"117","author":"Lindsey JW","year":"2008","journal-title":"Acta Neurol Scand"},{"key":"bibr20-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510364537"},{"key":"bibr21-1352458511410515","author":"Simon KC","year":"2010","journal-title":"Acta Neurol Scand"},{"key":"bibr22-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00394.x"},{"key":"bibr23-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072397"},{"key":"bibr24-1352458511410515","doi-asserted-by":"publisher","DOI":"10.1038\/nm1670"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511410515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458511410515","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511410515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:31:37Z","timestamp":1777692697000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458511410515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1177\/1352458511410515"],"URL":"https:\/\/doi.org\/10.1177\/1352458511410515","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}