{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:09:05Z","timestamp":1788577745913,"version":"build-2803163510"},"reference-count":5,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T00:00:00Z","timestamp":1323129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>As there is little information regarding the recovery from Uhthoff phenomenon (UP) in the multiple sclerosis (MS) literature, the objective of this study was to assess the phenotypes of UP. A one-page questionnaire was sent to 80 consecutive optic neuritis (ON) patients seen in a tertiary neuro-ophthalmology clinic. Of the 48 responders to the questionnaire, 52% reported experiencing UP, with a range of follow-up from 1 to 20 years. Only 16% had resolution of UP, all this occurred within 8 weeks of the onset of ON. Of the MS patients with UP, 88% experienced non-visual heat-related phenomenon compared with 30% without UP. The presence of UP may have a more general phenotypic significance. If full recovery from UP has not occurred within the first 2 months from the onset of ON, then recovery appears to be uncommon and may therefore be a surrogate marker of remyelination in future drug trials.<\/jats:p>","DOI":"10.1177\/1352458511431074","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T21:54:15Z","timestamp":1323208455000},"page":"1042-1044","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The time course and phenotype of Uhthoff phenomenon following optic neuritis"],"prefix":"10.1177","volume":"18","author":[{"given":"Clare L","family":"Fraser","sequence":"first","affiliation":[{"name":"Department of Neuro-ophthalmology, Moorfields Eye Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indran","family":"Davagnanam","sequence":"additional","affiliation":[{"name":"Brain Repair and Rehabilitation Unit, Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Radon","sequence":"additional","affiliation":[{"name":"Lysholm Department of Neuro-radiology, The National Hospital for Neurology and Neurosurgery, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon T","family":"Plant","sequence":"additional","affiliation":[{"name":"Department of Neuro-ophthalmology, Moorfields Eye Hospital, London, UK"},{"name":"Department of Neuro-ophthalmology, The National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,6]]},"reference":[{"key":"bibr1-1352458511431074","doi-asserted-by":"publisher","DOI":"10.1159\/000305926"},{"key":"bibr2-1352458511431074","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-005-0051-y"},{"key":"bibr3-1352458511431074","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490230023001"},{"key":"bibr4-1352458511431074","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.1.60"},{"key":"bibr5-1352458511431074","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300209"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511431074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458511431074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511431074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:33:01Z","timestamp":1777692781000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458511431074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,6]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1177\/1352458511431074"],"URL":"https:\/\/doi.org\/10.1177\/1352458511431074","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,6]]}}}