{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:17:25Z","timestamp":1785291445620,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Factors determining severity and recovery of early demyelinating events in pediatric multiple sclerosis (MS) patients are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to characterize the severity and recovery of early demyelinating events in pediatric MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Multivariate logistic regression was performed to determine predictors of severe (versus mild\/moderate) relapses and poor or fair (versus complete) recovery in patients aged 18 years or less with MS or clinically isolated syndrome (CIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Optic nerve involvement (OR 4.30, 95% CI 1.50\u201312.3, p = 0.007) was associated with a severe initial demyelinating event (IDE), while non-White race (OR 2.55, 95% CI 0.87\u20137.49, p = 0.088), localization to the cerebral hemispheres (OR 7.94, 95% CI 0.86\u201373.8, p = 0.068), or encephalopathy (OR 8.70, 95% CI 0.86\u201388.0, p = 0.067) showed a trend towards increased IDE severity. A similar association with race was found for severe second events. A severe IDE (OR 6.90, 95% CI 2.47\u201319.3, p &lt; 0.001) was associated with incomplete IDE recovery, with similar trends for second and third events. Incomplete recovery from the first event predicted incomplete second event recovery (OR 3.36, 95% CI 0.98\u201311.6, p = 0.055).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results may help identify children at risk for a more aggressive disease course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458511431725","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:08:39Z","timestamp":1324339719000},"page":"1008-1012","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Relapse severity and recovery in early pediatric multiple sclerosis"],"prefix":"10.1177","volume":"18","author":[{"given":"Alex J","family":"Fay","sequence":"first","affiliation":[{"name":"Department of Pediatrics, St Louis Children\u2019s Hospital, St Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M","family":"Mowry","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Francisco, CA, USA"},{"name":"Department of Neurology, Multiple Sclerosis Center, University of California, San Francisco, CA, USA"},{"name":"Regional Pediatric Multiple Sclerosis Center, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Strober","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Francisco, CA, USA"},{"name":"Department of Neurology, Multiple Sclerosis Center, University of California, San Francisco, CA, USA"},{"name":"Regional Pediatric Multiple Sclerosis Center, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Waubant","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Francisco, CA, USA"},{"name":"Department of Neurology, Multiple Sclerosis Center, University of California, San Francisco, CA, USA"},{"name":"Regional Pediatric Multiple Sclerosis Center, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"bibr1-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067597"},{"key":"bibr2-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70196-5"},{"key":"bibr3-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.1006"},{"key":"bibr4-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1177\/135245859700300105"},{"key":"bibr5-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508101933"},{"key":"bibr6-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.135"},{"key":"bibr7-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg081"},{"key":"bibr8-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.635"},{"key":"bibr9-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342458.39625.91"},{"key":"bibr10-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259422.44235.a8"},{"key":"bibr11-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1162\/089976603321891864"},{"key":"bibr12-1352458511431725","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801888"},{"key":"bibr13-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21916"},{"key":"bibr14-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.03.020"},{"key":"bibr15-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02451.2002"},{"key":"bibr16-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.06.008"},{"key":"bibr17-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-1004-6"},{"key":"bibr18-1352458511431725","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn098"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511431725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458511431725","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511431725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:33:06Z","timestamp":1777692786000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458511431725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,19]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1177\/1352458511431725"],"URL":"https:\/\/doi.org\/10.1177\/1352458511431725","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,19]]}}}