{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:14:40Z","timestamp":1777936480446,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the effects of intravenous natalizumab and intramuscular interferon beta-1a (IFN\u03b2-1a) on the volume of white-matter (WM) lesions and normal appearing brain tissue (NABT) undergoing voxel-wise (VW) increases in magnetization transfer ratio (MTR) suggestive of remyelination in patients with relapsing multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective, open-label, single-blinded study enrolled patients with relapsing\u2013remitting multiple sclerosis (RRMS) and relapsing secondary progressive multiple sclerosis (RSPMS) as well as a group of age\/sex-matched healthy controls ( n=22). Patients with multiple sclerosis were assigned to receive natalizumab monotherapy ( n=77; RRMS\/RSPMS) or intramuscular IFN\u03b2-1a ( n=26) as either monotherapy (RRMS) or combined with pulsed i.v. methylprednisolone, as needed (RSPMS). The primary endpoint was the two-year change in volume of NABT VWMTR, by quantifying the number of voxels that increased (suggesting remyelination) or decreased (suggesting demyelination) in their MTR value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The volume of tissue undergoing increases in VWMTR was significantly larger in natalizumab compared with IFN\u03b2-1a-treated patients (year 1: p=0.001 in NABT and p&lt;0.006 in WM lesions; year 2: p=0.008 in NABT) and compared with healthy control subjects (year 1: p=0.05 and year 2: p=0.007 in NABT). The larger volume within NABT undergoing decreases in VWMTR was detected in multiple sclerosis patients compared with healthy controls ( p&lt;0.001), and in the IFN\u03b2-1a group compared with the natalizumab group (year 1: p=0.05; year 2: p=0.002). One patient on natalizumab died from progressive multifocal leukoencephalopathy eight months after completing the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Natalizumab may promote remyelination and stabilize demyelination in lesions and NABT in relapsing multiple sclerosis, compared with intramuscular IFN\u03b2-1a.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458511433304","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T22:35:12Z","timestamp":1324593312000},"page":"1125-1134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Voxel-wise magnetization transfer imaging study of effects of natalizumab and IFN\u03b2-1a in multiple sclerosis"],"prefix":"10.1177","volume":"18","author":[{"given":"R","family":"Zivadinov","sequence":"first","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"},{"name":"The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MG","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hussein","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Carl","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Andrews","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hojnacki","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Heininen-Brown","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, 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