{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:23:02Z","timestamp":1785198182920,"version":"3.55.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Previous infection with Epstein\u2013Barr virus (EBV) and infectious mononucleosis are established multiple sclerosis (MS) risk factors, and elevated serum titers of anti-EBV nuclear antigen (anti-EBNA) antibodies in healthy adults are strongly correlated with future MS risk. In this prospective study, we investigated the association between EBV neutralizing antibodies and MS risk. MS risk tended to be higher in individuals with high titers of neutralizing antibodies compared to those with low titers (relative risk [RR] = 2.2, 95% confidence interval [CI] 0.97\u20135.1). This association was attenuated after adjustment for anti-EBNA1 IgG Ab titers (RR = 1.4, 95% CI 0.5\u20133.5). This preliminary finding warrants further study in a larger population.<\/jats:p>","DOI":"10.1177\/1352458511433920","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T01:54:12Z","timestamp":1327974852000},"page":"1185-1187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Epstein\u2013Barr virus neutralizing antibody levels and risk of multiple sclerosis"],"prefix":"10.1177","volume":"18","author":[{"given":"Kelly Claire","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, MA, USA"},{"name":"Channing Laboratory, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilis J","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassandra L","family":"Munger","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Finerty","sequence":"additional","affiliation":[{"name":"School of Cellular and Molecular Medicine, Medical Sciences Building, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Cellular and Molecular Medicine, Medical Sciences Building, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ascherio","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, MA, USA"},{"name":"Channing Laboratory, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"},{"name":"Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,1,30]]},"reference":[{"key":"bibr1-1352458511433920","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/ana.21978","volume":"67","author":"Levin LI","year":"2010","journal-title":"Ann Neurol"},{"key":"bibr2-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-010-9201-3"},{"key":"bibr3-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21117"},{"key":"bibr4-1352458511433920","volume-title":"Human Herpesviruses: Biology, Therapy and Immunoprophylaxis","author":"Morgan AJ","year":"2007"},{"key":"bibr5-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.61.5.1416-1420.1987"},{"key":"bibr6-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1086\/523813"},{"key":"bibr7-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03005.x"},{"key":"bibr8-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.24.3083"},{"key":"bibr9-1352458511433920","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(98)00054-8"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511433920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458511433920","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458511433920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:33:21Z","timestamp":1777692801000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458511433920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,30]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1177\/1352458511433920"],"URL":"https:\/\/doi.org\/10.1177\/1352458511433920","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,30]]}}}