{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:15:02Z","timestamp":1777936502440,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T00:00:00Z","timestamp":1341273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Advances in the understanding of central nervous system aquarporin-4 autoimmunity have promoted the recognition of diverse clinical presentations beyond the traditional view of neuromyelitis optica. We describe a patient who developed hemiparesis caused by an extensive cerebral lesion as an initial manifestation of central nervous system aquarporin-4 autoimmunity. Although the patient had no history of optic neuritis or myelitis, not only was serum anti-aquarporin-4 antibody positive, but an imaging, treatment response and histopathological features also revealed characteristic findings suggestive of central nervous system aquarporin-4 autoimmunity. The present case highlights the importance of a comprehensive evaluation for anti-aquarporin-4 antibody even in patients presenting with isolated cerebral lesions.<\/jats:p>","DOI":"10.1177\/1352458512441271","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T17:50:12Z","timestamp":1341424212000},"page":"1340-1343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Central nervous system aquaporin-4 autoimmunity presenting with an isolated cerebral abnormality"],"prefix":"10.1177","volume":"18","author":[{"given":"Su-Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woojun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong-Cherl","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Pathology, Research Institute and Hospital of National Cancer Center, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-kyung","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Research Institute and Hospital of National Cancer Center, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"bibr1-1352458512441271","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.3.115"},{"key":"bibr2-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.08.032"},{"key":"bibr3-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510376640"},{"key":"bibr4-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511404917"},{"key":"bibr5-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511424590"},{"key":"bibr6-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2008.00288.x"},{"key":"bibr7-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300403"},{"key":"bibr8-1352458512441271","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4295"},{"key":"bibr9-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm047"},{"key":"bibr10-1352458512441271","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.62"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512441271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458512441271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512441271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:34:02Z","timestamp":1777692842000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458512441271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,3]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/1352458512441271"],"URL":"https:\/\/doi.org\/10.1177\/1352458512441271","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,3]]}}}