{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:31:33Z","timestamp":1792737093788,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T00:00:00Z","timestamp":1346284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Retinal nerve fibre layer (RNFL) thinning is associated with brain atrophy in multiple sclerosis (MS). An influence of optic neuritis is well documented but sparsely investigated. Recently, the retinal ganglion cell layer (GCL) has been shown to provide superior information regarding visual function and retinal neurodegeneration as compared with RNFL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association of white and grey matter brain volume with peripapillary RNFL and macular GCL in MS patients with and without a history of optic neuritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>63 patients with relapsing\u2013remitting MS were included in a two-centre cross-sectional prospective study. All patients underwent retinal examination with spectral domain optical coherence tomography and 1.5 T MRI for determination of normalized brain volume (NBV), white matter volume (NWMV) and grey matter volume (NGMV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both RNFL and GCL were associated with NBV, NWMV and NGMV in eyes without previous optic neuritis. This association is disrupted in the case of NGMV following optic neuritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Both RNFL and GCL as parameters of neuro-axonal damage are comparably linked to whole brain as well as white and grey matter atrophy. An event of optic neuritis interferes with this relation, adding further damage to the optic nerve and disrupting especially an association with grey matter.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458512457844","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T01:27:25Z","timestamp":1346376445000},"page":"443-450","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":97,"title":["Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations"],"prefix":"10.1177","volume":"19","author":[{"given":"Hanna","family":"Zimmermann","sequence":"first","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Freing","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Kaufhold","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gaede","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bohn","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bock","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Oberwahrenbrock","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Lea","family":"Young","sequence":"additional","affiliation":[{"name":"Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (inims), University Medical Centre Hamburg Eppendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens T","family":"Wuerfel","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"},{"name":"Department of Neuroradiology, University Medicine Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Schippling","sequence":"additional","affiliation":[{"name":"Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (inims), University Medical Centre Hamburg Eppendorf, Germany"},{"name":"Department of Neuroimmunology and Clinical Multiple Sclerosis Research, Neurology Clinic, University Medical Centre Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"},{"name":"Clinical and Experimental Multiple Sclerosis Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander U","family":"Brandt","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Centre and Experimental and Clinical Research Centre, Charit\u00e9-Universit\u00e4tsmedizin Berlin and Max Delbrueck Centre for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8,30]]},"reference":[{"key":"bibr1-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7"},{"key":"bibr2-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.1.65"},{"key":"bibr3-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21719"},{"key":"bibr4-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.8.1157"},{"key":"bibr5-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70349-0"},{"key":"bibr6-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.567"},{"key":"bibr7-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70573-7"},{"key":"bibr8-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70168-X"},{"key":"bibr9-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036847"},{"key":"bibr10-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/530305"},{"key":"bibr11-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"bibr12-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260612.51849.ed"},{"key":"bibr13-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0985-5"},{"key":"bibr14-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.10.020"},{"key":"bibr15-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.04.010"},{"key":"bibr16-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018019"},{"key":"bibr17-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018132"},{"key":"bibr18-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013877"},{"key":"bibr19-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510365156"},{"key":"bibr20-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq346"},{"key":"bibr21-1352458512457844","unstructured":"Syc SB, Saidha S, Newsome SD, Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis. Brain 2011. Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22006982 (accessed 14 January 2012)."},{"key":"bibr22-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"key":"bibr23-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"bibr24-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200105000-00022"},{"key":"bibr25-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1040"},{"key":"bibr26-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"bibr27-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"bibr28-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"bibr29-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"bibr30-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"bibr31-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr095"},{"key":"bibr32-1352458512457844","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq080"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512457844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458512457844","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512457844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:35:24Z","timestamp":1777692924000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458512457844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,30]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1177\/1352458512457844"],"URL":"https:\/\/doi.org\/10.1177\/1352458512457844","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,30]]}}}