{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:22:54Z","timestamp":1793398974247,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Multiple sclerosis (MS) and neuromyelitis optica (NMO) are immune-mediated inflammatory diseases of the central nervous system. In the acute phase of these diseases, secondary ischemia due to inflammation-induced endothelial dysfunction may be an important pathological change. Pentraxin 3 (PTX3) is a pro-inflammatory protein and a novel biomarker of inflammatory vascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to determine whether PTX3 levels are elevated in MS and NMO patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The concentrations of plasma PTX3 were measured using an enzyme-linked immunosorbent assay in 22 MS patients, 26 NMO patients, 15 acute cerebral infarction (CI) patients, 11 mild headache patients, and 14 volunteer controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>During relapse, plasma PTX3 levels were higher in MS patients than in headache patients ( p=0.003) and controls ( p&lt;0.001). Plasma PTX3 levels were also increased in NMO patients compared with CI patients ( p=0.011), headache patients ( p&lt;0.001) and controls ( p&lt;0.001). CI patients showed elevated PTX3 levels compared with controls ( p=0.008). MS and NMO patients showed a trend toward an increased disease disability with higher plasma PTX3 during relapse (MS: p=0.005; NMO: p&lt;0.001). Plasma PTX3 levels were remarkably lower in remission than in the relapse stage (MS: p&lt;0.001; NMO: p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Plasma PTX3 level is associated with inflammatory responses in MS and NMO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458512457845","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T22:49:09Z","timestamp":1348786149000},"page":"926-931","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica"],"prefix":"10.1177","volume":"19","author":[{"given":"Honghao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, China"},{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The First Affiliated Hospital of Anhui Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"bibr1-1352458512457845","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506075651"},{"key":"bibr2-1352458512457845","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03066.x"},{"key":"bibr3-1352458512457845","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1444.002"},{"key":"bibr4-1352458512457845","first-page":"1195","volume":"42","author":"Fujihara K","year":"2002","journal-title":"Rinsho 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