{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:15:47Z","timestamp":1777936547868,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T00:00:00Z","timestamp":1350259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Tumor necrosis factor alpha (TNF-\u03b1) is a pro-inflammatory and immunoregulatory cytokine involved in the pathogenesis of several autoimmune disorders. Etanercept, a TNF-\u03b1 antagonist (anti-TNF-\u03b1) acting as a soluble TNF-\u03b1 receptor, has been associated with neurological demyelinating disorders. This paper aims to report an unusual case showing tumefactive central nervous system (CNS) inflammatory demyelination in a patient in the course of TNF -\u03b1 antagonist therapy, requiring decompressive hemicraniectomy. This report is based on magnetic resonance imaging (MRI) findings and histology. A biopsy confirmed the inflammatory demyelinating nature of the lesions. The clinical presentation is unusual due to the severity of the disease process, requiring decompressive hemicraniotomy with a clinically favorable outcome.<\/jats:p>","DOI":"10.1177\/1352458512461969","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T23:47:46Z","timestamp":1350344866000},"page":"820-823","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Tumefactive demyelinating lesions during etanercept treatment requiring decompressive hemicraniectomy"],"prefix":"10.1177","volume":"19","author":[{"given":"CW","family":"Cereda","sequence":"first","affiliation":[{"name":"Neurology, Neurocenter of Southern Switzerland (EOC), Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Zecca","sequence":"additional","affiliation":[{"name":"Neurology, Neurocenter of Southern Switzerland (EOC), Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mazzucchelli","sequence":"additional","affiliation":[{"name":"Servizio Cantonale di Patologia, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Valci","sequence":"additional","affiliation":[{"name":"Neurosurgery, Neurocenter of Southern Switzerland (EOC), Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Staedler","sequence":"additional","affiliation":[{"name":"Neurology, Neurocenter of Southern Switzerland (EOC), Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Neurology Inselspital Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Neurology, Neurocenter of Southern Switzerland (EOC), Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,15]]},"reference":[{"key":"bibr1-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5591-7"},{"key":"bibr2-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.10.003"},{"key":"bibr3-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W"},{"key":"bibr4-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.11.002"},{"key":"bibr5-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9420-8"},{"key":"bibr6-1352458512461969","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2010.544784"},{"key":"bibr7-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000073540.35919.AE"},{"key":"bibr8-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000156201.46473.A8"},{"key":"bibr9-1352458512461969","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.142133"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512461969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458512461969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512461969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:35:54Z","timestamp":1777692954000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458512461969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,15]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1177\/1352458512461969"],"URL":"https:\/\/doi.org\/10.1177\/1352458512461969","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,15]]}}}