{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:16:01Z","timestamp":1777936561078,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>We observed two cases of progressive multifocal leukoencephalopathy (PML) that occurred in the same \u201cinfusion group\u201d. The group consisted of four patients with relapsing\u2013remitting multiple sclerosis (RRMS) who had been treated with natalizumab (NAT) in the same medical practice for more than four years at the same times and in the same room, raising concerns about viral transmission between members of the infusion group.<\/jats:p>\n                  <jats:p>DNA amplification and sequence comparison of the non-coding control region (NCCR) of JC virus (JCV) present in cerebrospinal fluid (CSF) samples from PML patients #1 and #2 revealed that the amplified JCV sequences differed from the JCV archetype. The NCRR of the viral DNA was unique to each patient, arguing against the possibility of viral transmission between patients. Statistical considerations predict that similar co-occurrences of PML are likely to happen in the future.<\/jats:p>","DOI":"10.1177\/1352458512466165","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T02:39:24Z","timestamp":1351823964000},"page":"1213-1215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Co-occurrence of two cases of progressive multifocal leukoencephalopathy in a natalizumab \u201cinfusion group\u201d"],"prefix":"10.1177","volume":"19","author":[{"given":"J","family":"Havla","sequence":"first","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Berthele","sequence":"additional","affiliation":[{"name":"Department of Neurology, Technische Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"K\u00fcmpfel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Krumbholz","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Jochim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Technische Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kronsbein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Technische Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ryschkewitsch","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, National Institutes of Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jensen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, National Institutes of Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Lippmann","sequence":"additional","affiliation":[{"name":"Practice of Dr Bergmann\/Dr Lippmann, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Technische Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Major","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, National Institutes of Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hohlfeld","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"bibr1-1352458512466165","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70149-1"},{"key":"bibr2-1352458512466165","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823b9b27"},{"key":"bibr3-1352458512466165","doi-asserted-by":"publisher","DOI":"10.1080\/13550280152537102"},{"key":"bibr4-1352458512466165","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.51.2.458-469.1984"},{"key":"bibr5-1352458512466165","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.29.10.2130-2138.1991"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512466165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458512466165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458512466165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:36:13Z","timestamp":1777692973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458512466165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1177\/1352458512466165"],"URL":"https:\/\/doi.org\/10.1177\/1352458512466165","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,1]]}}}