{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:16:22Z","timestamp":1777936582917,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/objective:<\/jats:title>\n                    <jats:p>Retinal nerve fiber layer (RNFL) thickness has been linked to brain atrophy in multiple sclerosis (MS). However, little is known about retinal atrophy in \u2018benign\u2019 MS. We compared RNFL thickness in benign MS with healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with benign MS (Expanded Disability Status Scale (EDSS) \u2264 3; \u226515 years\u2019 disease duration), identified through the British Columbia MS database, along with age-matched healthy controls, were recruited. RNFL thickness was measured using spectral-domain optical coherence tomography. Analysis of variance (ANOVA) was used to compare groups. The association between RNFL thickness and MS patient characteristics was examined via linear mixed-effects models (adjusting for within-patient inter-eye correlations and history of optic neuritis (ON), where appropriate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 29 benign MS patients and 29 healthy controls were included, totaling 116 eyes. RNFL thickness was lowest for the benign MS eyes, with and then without a history of ON, followed by healthy controls (mean=73.2 \u00b5m, SD \u00b1 0.4; 89.9 \u00b5m, SD \u00b1 12.5; 96.7 \u00b5m, SD \u00b1 10.4; p&lt;0.02). RNFL thickness was associated with a history of ON ( p&lt;0.0001), but not EDSS or disease duration ( p&gt;0.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>RNFL thickness was lower in patients with benign MS than healthy controls, regardless of the previous history of ON. However, no association was found between RNFL values and disability or MS disease duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458512474706","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T21:53:10Z","timestamp":1360619590000},"page":"1275-1281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Retinal nerve fiber layer thickness in benign multiple sclerosis"],"prefix":"10.1177","volume":"19","author":[{"given":"Alex P","family":"Lange","sequence":"first","affiliation":[{"name":"Neuro-Ophthalmology, Department of Ophthalmology, University of British Columbia, Canada"},{"name":"Vista Klinik, Vista Diagnostics and Laser Vista, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Faculty and Department of Medicine, Division of Neurology, University of British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Luiza","family":"Sayao","sequence":"additional","affiliation":[{"name":"Faculty and Department of Medicine, Division of Neurology, University of British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Sadjadi","sequence":"additional","affiliation":[{"name":"Faculty and Department of Medicine, Division of Neurology, University of British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Alkabie","sequence":"additional","affiliation":[{"name":"Faculty and Department of Medicine, Division of Neurology, University of British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony L","family":"Traboulsee","sequence":"additional","affiliation":[{"name":"Faculty and Department of Medicine, Division of Neurology, University of British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Costello","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurosciences and Surgery (Ophthalmology), University of Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Tremlett","sequence":"additional","affiliation":[{"name":"Faculty and Department of Medicine, Division of Neurology, University of British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,11]]},"reference":[{"key":"bibr1-1352458512474706","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"bibr2-1352458512474706","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(77)90010-8"},{"key":"bibr3-1352458512474706","first-page":"69","volume":"58","author":"Thompson AJ","year":"1986","journal-title":"Q J 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