{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:16:14Z","timestamp":1777936574876,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T00:00:00Z","timestamp":1359936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Although it is debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients undergo endovascular treatment (ET) of CCSVI. A study is ongoing in Italy to evaluate the clinical outcome of ET. Severe adverse events (AEs) occurred in 15\/462 subjects at a variable interval after ET: jugular thrombosis in seven patients, tetraventricular hydrocephalus, stroke, paroxysmal atrial fibrillation, status epilepticus, aspiration pneumonia, hypertension with tachicardia, or bleeding of bedsore in the remaining seven cases. One patient died because of myocardial infarction 10 weeks after ET. The risk of severe AEs related to ET for CCSVI must be carefully considered.<\/jats:p>","DOI":"10.1177\/1352458513475491","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T20:49:29Z","timestamp":1360010969000},"page":"961-963","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Adverse events after endovascular treatment of chronic cerebro-spinal venous insufficiency (CCSVI) in patients with multiple sclerosis"],"prefix":"10.1177","volume":"19","author":[{"given":"A","family":"Ghezzi","sequence":"first","affiliation":[{"name":"Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Annovazzi","sequence":"additional","affiliation":[{"name":"Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MP","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Neurosciences \u2014 University of Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Capello","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Cavalla","sequence":"additional","affiliation":[{"name":"Clinica Neurologica, Universit\u00e0 di Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Cocco","sequence":"additional","affiliation":[{"name":"Centro Sclerosi Multipla, Dipartimento di Sanit\u00e0 Pubblica, Medicina Clinica e Molecolare, University of Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Falcini","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Ospedale Misericordia e Dolce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gallo","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre, I Division of Neurology, Second University of Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Patti","sequence":"additional","affiliation":[{"name":"DANA GF Ingrassia, Neuroscience Section, Multiple Sclerosis Center, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Perini","sequence":"additional","affiliation":[{"name":"Neurological Department, Azienda Ospedaliera Universit\u00e0 di Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ME","family":"Rodegher","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rovaris","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Fondazione Don Gnocchi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MR","family":"Rottoli","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Dipartimento di Chirurgia del Sistema Nervoso e Neuroscienze, Ospedali Riuniti Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Comi","sequence":"additional","affiliation":[{"name":"Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy"},{"name":"Department of Neurology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the MS Study Group-Italian Society of Neurology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,4]]},"reference":[{"key":"bibr1-1352458513475491","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.07.096"},{"key":"bibr2-1352458513475491","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2010.010053"},{"key":"bibr3-1352458513475491","first-page":"557","volume":"32","author":"Kostecki J","year":"2011","journal-title":"Neuro Endocrinol Lett"},{"key":"bibr4-1352458513475491","doi-asserted-by":"publisher","DOI":"10.1583\/11-3440.1"},{"key":"bibr5-1352458513475491","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.09.019"},{"key":"bibr6-1352458513475491","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.03.035"},{"key":"bibr7-1352458513475491","first-page":"55","volume":"27","author":"Salvi F","year":"2012","journal-title":"Funct Neurol"},{"key":"bibr8-1352458513475491","unstructured":"United States Food and Drug Administration. 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