{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:15:33Z","timestamp":1790306133899,"version":"4.1.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the \u201cCIS only\u201d condition. The study was based on the longitudinally followed Gothenburg 1950\u20131964 incidence cohort ( n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained \u201cCIS only\u201d. Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining \u201cCIS only\u201d. Patients who had experienced no relapse during the first 25 years remained \u201cCIS only\u201d for the subsequent 25 years of follow-up.<\/jats:p>","DOI":"10.1177\/1352458513496345","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T23:34:15Z","timestamp":1374190455000},"page":"496-500","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy"],"prefix":"10.1177","volume":"20","author":[{"given":"L","family":"Novakova","sequence":"first","affiliation":[{"name":"Section of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Skoog","sequence":"additional","affiliation":[{"name":"Section of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Runmarker","sequence":"additional","affiliation":[{"name":"Section of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ekholm","sequence":"additional","affiliation":[{"name":"Department of Imaging Sciences, University of Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Winblad","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Lisovskaja","sequence":"additional","affiliation":[{"name":"Institute of Mathematical Statistics, Chalmers Technical University, and Institute of Mathematical Statistics, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Andersen","sequence":"additional","affiliation":[{"name":"Section of Clinical Neuroscience and Rehabilitation, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"bibr1-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70071-5"},{"key":"bibr2-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0655-9"},{"key":"bibr3-1352458513496345","first-page":"727","volume":"65","author":"Group TONS","year":"2008","journal-title":"Arch Neurol"},{"key":"bibr4-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm329"},{"key":"bibr5-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr336"},{"key":"bibr6-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.1.117"},{"key":"bibr7-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr8-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511426740"},{"key":"bibr9-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms914oa"},{"key":"bibr10-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360703"},{"key":"bibr11-1352458513496345","first-page":"91","volume-title":"Multiple sclerosis, clinical and pathogenetic basis","author":"Kurtzke JF","year":"1997"},{"key":"bibr12-1352458513496345","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.127"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458513496345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458513496345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458513496345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:38:13Z","timestamp":1777693093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458513496345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1177\/1352458513496345"],"URL":"https:\/\/doi.org\/10.1177\/1352458513496345","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]}}}