{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:17:02Z","timestamp":1777936622728,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neuromyelitis optica (NMO) and multiple sclerosis (MS), two inflammatory demyelinating diseases, are characterized by different therapeutic strategies. Currently, the only biological diagnostic tool available to distinguish NMO from MS is the specific serum autoantibody that targets aquaporin 4, but its sensitivity is low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the diagnostic accuracy of metabolomic biomarker profiles in these two neurological conditions, compared to control patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We acquired serum spectra (47 MS, 44 NMO and 42 controls) using proton nuclear magnetic resonance (\n                      <jats:sup>1<\/jats:sup>\n                      H-NMR) spectroscopy. We used multivariate pattern recognition analysis to identify disease-specific metabolic profiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:sup>1<\/jats:sup>\n                      H-NMR spectroscopic analysis evidenced two metabolites, originating probably from astrocytes, scyllo-inositol and acetate, as promising serum biomarkers of MS and NMO, respectively. In 87.8% of MS patients, scyllo-inositol increased 0.15 to 3-fold, compared to controls and in 74.3% of NMO patients, acetate increased 0.4 to 7-fold, compared to controls. Using these two metabolites simultaneously, we can discriminate MS versus NMO patients (sensitivity, 94.3%; specificity, 90.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      This study demonstrates the potential of\n                      <jats:sup>1<\/jats:sup>\n                      H-NMR spectroscopy of serum as a novel, promising analytical tool to discriminate populations of patients affected by NMO or MS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458513504638","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T04:06:01Z","timestamp":1380600361000},"page":"558-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Serum analysis by\n                    <sup>1<\/sup>\n                    H Nuclear Magnetic Resonance spectroscopy: a new tool for distinguishing neuromyelitis optica from multiple sclerosis"],"prefix":"10.1177","volume":"20","author":[{"given":"F-M","family":"Moussallieh","sequence":"first","affiliation":[{"name":"ICube, Universit\u00e9 de Strasbourg, France"},{"name":"Service de Biophysique et M\u00e9decine Nucl\u00e9aire, Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Elbayed","sequence":"additional","affiliation":[{"name":"ICube, Universit\u00e9 de Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JB","family":"Chanson","sequence":"additional","affiliation":[{"name":"Service de Neurologie, H\u00f4pital de Hautepierre, Strasbourg, France"},{"name":"Facult\u00e9 de M\u00e9decine, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale), Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Rudolf","sequence":"additional","affiliation":[{"name":"Service de Neurologie, H\u00f4pital de Hautepierre, Strasbourg, France"},{"name":"Facult\u00e9 de M\u00e9decine, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale), Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Piotto","sequence":"additional","affiliation":[{"name":"ICube, Universit\u00e9 de Strasbourg, France"},{"name":"Bruker BioSpin, Wissembourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"De Seze","sequence":"additional","affiliation":[{"name":"Service de Neurologie, H\u00f4pital de Hautepierre, Strasbourg, France"},{"name":"Facult\u00e9 de M\u00e9decine, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale), Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IJ","family":"Namer","sequence":"additional","affiliation":[{"name":"ICube, Universit\u00e9 de Strasbourg, France"},{"name":"Service de Biophysique et M\u00e9decine Nucl\u00e9aire, Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"bibr1-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"bibr2-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms947oa"},{"key":"bibr3-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr4-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"bibr5-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"bibr6-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507084595"},{"key":"bibr7-1352458513504638","unstructured":"M\u00e9thode de diagnostic diff\u00e9rentiel discriminant la scl\u00e9rose en plaque de la maladie de Devic. 2012."},{"key":"bibr8-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"key":"bibr9-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506070732"},{"key":"bibr10-1352458513504638","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/nbm.1428","volume":"23","author":"Sinclair AJ","year":"2010","journal-title":"NMR Biomed"},{"key":"bibr11-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.3915"},{"key":"bibr12-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00224-9"},{"key":"bibr13-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000595"},{"key":"bibr14-1352458513504638","doi-asserted-by":"publisher","DOI":"10.2174\/138920111795909122"},{"key":"bibr15-1352458513504638","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1385272803666220131194702","volume":"3","author":"Lippens G","year":"1999","journal-title":"Curr Org Chem"},{"key":"bibr16-1352458513504638","doi-asserted-by":"crossref","unstructured":"Meiboom S, Gill D. Modified spin echo method for measuring nuclear relaxation times. Rev Sci Instrum 1958; 29: 688\u2013691. doi: http:\/\/dx.doi.org\/10.1063\/1.1716296.","DOI":"10.1063\/1.1716296"},{"key":"bibr17-1352458513504638","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1017\/CBO9780511996634.027","volume-title":"Methodologies in metabolomics: Experimental strategies and techniques for metabolomics research","author":"Piotto M","year":"2013"},{"key":"bibr18-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24658"},{"key":"bibr19-1352458513504638","volume-title":"La r\u00e9gression PLS: Th\u00e9orie et pratique","author":"Tenenhaus M","year":"1998"},{"key":"bibr20-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-007-0099-6"},{"key":"bibr21-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1021\/ja055336t"},{"key":"bibr22-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1984.10478083"},{"key":"bibr23-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-7439(00)00122-2"},{"key":"bibr24-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.927"},{"key":"bibr25-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182309fa5"},{"key":"bibr26-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b1a8c"},{"key":"bibr27-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.168070"},{"key":"bibr28-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23909"},{"key":"bibr29-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302310"},{"key":"bibr30-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.84"},{"key":"bibr31-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.01.016"},{"key":"bibr32-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182887957"},{"key":"bibr33-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/398259"},{"key":"bibr34-1352458513504638","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.7.640"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458513504638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458513504638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458513504638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:38:46Z","timestamp":1777693126000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458513504638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,30]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1177\/1352458513504638"],"URL":"https:\/\/doi.org\/10.1177\/1352458513504638","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,30]]}}}