{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:37:29Z","timestamp":1792006649140,"version":"4.4.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Few data are available for patients with a late onset (\u2265 50 years) of neuromyelitis optica (LONMO) or neuromyelitis optica spectrum disease (LONMOSD), defined by an optic neuritis\/longitudinally extensive transverse myelitis with aquaporin-4 antibodies (AQP4-Ab).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To characterize LONMO and LONMOSD, and to analyze their predictive factors of disability and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We identified 430 patients from four cohorts of NMO\/NMOSD in France, Germany, Turkey and UK. We extracted the late onset patients and analyzed them for predictive factors of disability and death, using the Cox proportional model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We followed up on 63 patients with LONMO and 45 with LONMOSD during a mean of 4.6 years. This LONMO\/LONMOSD cohort was mainly of Caucasian origin (93%), women (80%), seropositive for AQP4-Ab (85%) and from 50 to 82.5 years of age at onset. No progressive course was noted. At last follow-up, the median Expanded Disability Status Scale (EDSS) scores were 5.5 and 6 in the LONMO and LONMOSD groups, respectively. Outcome was mainly characterized by motor disability and relatively good visual function. At last follow-up, 14 patients had died, including seven (50%) due to acute myelitis and six (43%) because of opportunistic infections. The EDSS 4 score was independently predicted by an older age at onset, as a continuous variable after 50 years of age. Death was predicted by two independent factors: an older age at onset and a high annualized relapse rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LONMO\/LONMOSD is particularly severe, with a high rate of motor impairment and death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458513515085","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T23:27:06Z","timestamp":1386631626000},"page":"1086-1094","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":108,"title":["Characterization of neuromyelitis optica and neuromyelitis optica spectrum disorder patients with a late onset"],"prefix":"10.1177","volume":"20","author":[{"given":"N","family":"Collongues","sequence":"first","affiliation":[{"name":"Department of Neurology, Hautepierre Hospital, University of Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Marignier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pierre Wertheimer Hospital, University of Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jacob","sequence":"additional","affiliation":[{"name":"The Walton Centre for Neurology and Neurosurgery, The Walton Centre Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MI","family":"Leite","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Siva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Paul","sequence":"additional","affiliation":[{"name":"Neurocure, Charit\u00e9 University Medicine Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Zephir","sequence":"additional","affiliation":[{"name":"Department of Neurology, Robert Salengro Hospital, University of Lille Nord de France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Akman-Demir","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Elsone","sequence":"additional","affiliation":[{"name":"The Walton Centre for Neurology and Neurosurgery, The Walton Centre Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Jarius","sequence":"additional","affiliation":[{"name":"Division of Molecular Neuroimmunology, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Papeix","sequence":"additional","affiliation":[{"name":"Department of Neurology, Groupe Hospitalier Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mutch","sequence":"additional","affiliation":[{"name":"The Walton Centre for Neurology and Neurosurgery, The Walton Centre Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Saip","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Wildemann","sequence":"additional","affiliation":[{"name":"Division of Molecular Neuroimmunology, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kitley","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Karabudak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Heinrich-Heine-University of D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kuscu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bak\u00fdrkoy Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Altintas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul University, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Palace","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Confavreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"De Seze","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hautepierre Hospital, University of Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"bibr1-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5780-4"},{"key":"bibr2-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d31e35"},{"key":"bibr3-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-14"},{"key":"bibr4-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.08.043"},{"key":"bibr5-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"bibr6-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"bibr7-1352458513515085","first-page":"99","volume":"15","author":"Waters P","year":"2008","journal-title":"MS Forum"},{"key":"bibr8-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.210.307"},{"key":"bibr9-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws109"},{"key":"bibr10-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f39a66"},{"key":"bibr11-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2758"},{"key":"bibr12-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000284600.80782.d5"},{"key":"bibr13-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000314832.24682.c6"},{"key":"bibr14-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300403"},{"key":"bibr15-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04210080082019"},{"key":"bibr16-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03435.x"},{"key":"bibr17-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.318"},{"key":"bibr18-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.417"},{"key":"bibr19-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr20-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040133"},{"key":"bibr21-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.11.2059"},{"key":"bibr22-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8561(02)00078-4"},{"key":"bibr23-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.06.011"},{"key":"bibr24-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000254502.87233.9a"},{"key":"bibr25-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.143529"},{"key":"bibr26-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.127"},{"key":"bibr27-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.249"},{"key":"bibr28-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318296e917"},{"key":"bibr29-1352458513515085","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb5c"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458513515085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458513515085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458513515085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:39:27Z","timestamp":1777693167000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458513515085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,9]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1177\/1352458513515085"],"URL":"https:\/\/doi.org\/10.1177\/1352458513515085","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,9]]}}}