{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:00:28Z","timestamp":1792155628252,"version":"4.4.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute transverse myelitis (ATM) in children is a rare and often severe disease for which there are few known prognostic factors, particularly the subsequent risk of multiple sclerosis (MS) diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the clinical course and prognostic factors after a first episode of ATM in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty children below 16 years of age diagnosed with a first neurological episode of ATM were included retrospectively. Clinical evaluation, treatment, laboratory, and MRI data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Median age at onset was 11 years (range 3\u201315 years). Follow-up data were available for a median of 4 years (range 0.5\u201316.7 years). Five patients subsequently had a diagnosis of MS (17%), which was associated with acute partial transverse myelitis (odds ratio 5; 95% confidence interval 2.3\u201311), with a 60% probability of having a relapse at five years ( p &lt; 0.01). The 2011 Verhey criteria correctly identified MS in children with the highest specificity (96%) and sensitivity (80%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acute partial transverse myelitis and brain MRI abnormalities at initial presentation are significantly predictive of a subsequent diagnosis of MS in children with ATM. These findings suggest that closer brain MRI monitoring after acute partial transverse myelitis might make the earlier introduction of disease-modifying therapies possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458514526943","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T22:24:20Z","timestamp":1394576660000},"page":"1485-1493","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Partial acute transverse myelitis is a predictor of multiple sclerosis in children"],"prefix":"10.1177","volume":"20","author":[{"given":"P","family":"Meyer","sequence":"first","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"},{"name":"INSERM U1046, Universit\u00e9 Montpellier 1, Universit\u00e9 Montpellier 2, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Leboucq","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neuroradiologie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Molinari","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Service DIM, Universit\u00e9 Montpellier 1, UMR 729 MISTEA, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Roubertie","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"},{"name":"INSERM U1051, Institut de Neurosciences de Montpellier, Universit\u00e9 Montpellier 1, Universit\u00e9 Montpellier 2, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Carneiro","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Walther-Louvier","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Cuntz-Shadfar","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"},{"name":"CHRU Montpellier, Neurophysiologie Clinique, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Leydet","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Cheminal","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Cambonie","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, R\u00e9animation P\u00e9diatrique, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Echenne","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Rondouin","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurophysiologie Clinique, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Deiva","sequence":"additional","affiliation":[{"name":"AP-HP, CHU Bic\u00eatre, Neurop\u00e9diatrie, Le Kremlin-Bic\u00eatre, France"},{"name":"National Referral Center for Neuro-Inflammatory Diseases in Children, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Mikaeloff","sequence":"additional","affiliation":[{"name":"AP-HP, CHU Bic\u00eatre, Unit\u00e9 de R\u00e9\u00e9ducation Neurologique Infantile, Le Kremlin Bic\u00eatre, France"},{"name":"INSERM U669, Universit\u00e9 Paris Sud11, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Rivier","sequence":"additional","affiliation":[{"name":"CHRU Montpellier, Neurop\u00e9diatrie, France"},{"name":"INSERM U1046, Universit\u00e9 Montpellier 1, Universit\u00e9 Montpellier 2, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"bibr1-1352458514526943","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000339482.84392.bd"},{"key":"bibr2-1352458514526943","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.12.002"},{"key":"bibr3-1352458514526943","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.499"},{"key":"bibr4-1352458514526943","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823dc535"},{"key":"bibr5-1352458514526943","doi-asserted-by":"crossref","unstructured":"Group TG-BSS. 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