{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:15:35Z","timestamp":1790306135653,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      An increasing women-to-men ratio in later birth cohorts of patients with multiple sclerosis (MS) has been observed in several populations and has been hypothesised to be due to one or several environmental factors of importance for disease aetiology. However, in a study based on data from the Swedish MS registry (SMSreg) this ratio was recently reported to be rather stable during the 20\n                      <jats:sup>th<\/jats:sup>\n                      century.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this study was to reinvestigate the women-to-men ratio in Sweden based on data from all available data sources, including deceased patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We combined data from the SMSreg with data from national patient registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total we obtained information on 19,510 MS patients born 1931\u20131985, 13,321 women and 6189 men. The women-to-men ratio increased from 1.70 for patients born in the 1930s to 2.67 for patients born in the 1980s. When comparing the coverage of SMSreg to the full data set, a significantly higher proportion of women born 1931\u20131935 compared to men born in the same period were found in SMSreg, resulting in a sampling bias hiding the increasing sex ratio in the full material.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The women-to-men ratio in MS has increased in Sweden during the 20\n                      <jats:sup>th<\/jats:sup>\n                      century similarly to observations in other western countries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458514530021","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:55:22Z","timestamp":1400547322000},"page":"1578-1583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["New data identify an increasing sex ratio of multiple sclerosis in Sweden"],"prefix":"10.1177","volume":"20","author":[{"given":"Helga","family":"Westerlind","sequence":"first","affiliation":[{"name":"Karolinska Institutet, The Multiple Sclerosis Research Group, Tomebodav\u00e4gen 18A:05, Stockholm, Solna, 17177, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Bostr\u00f6m","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Stawiarz","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Landtblom","sequence":"additional","affiliation":[{"name":"Link\u00f6ping University, Sweden\/Neurology Unit, General Hospital, Motala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Almqvist","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Sweden\/Lung and Allergy Unit Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital, Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hillert","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"bibr1-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70064-8"},{"key":"bibr2-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70581-6"},{"key":"bibr3-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6814-x"},{"key":"bibr4-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048078"},{"key":"bibr5-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512446169"},{"key":"bibr6-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512446169"},{"key":"bibr7-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"bibr8-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt356"},{"key":"bibr9-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1159\/000110529"},{"key":"bibr10-1352458514530021","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2013"},{"key":"bibr11-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31821c7adc"},{"key":"bibr12-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513481397"},{"key":"bibr13-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2011.03.001"},{"key":"bibr14-1352458514530021","unstructured":"Folkh\u00e4lsoinstitutet. Tobaksvanor, tidsserier och regionala resultat, 2012. \u201chttp:\/\/www.folkhalsomyndigheten.se\/\u201d www.folkhalsomyndigheten.se (accessed 14 November 2013)."},{"key":"bibr15-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"bibr16-1352458514530021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02850.x"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458514530021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458514530021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458514530021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:40:35Z","timestamp":1777693235000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458514530021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1177\/1352458514530021"],"URL":"https:\/\/doi.org\/10.1177\/1352458514530021","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]}}}