{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T21:42:54Z","timestamp":1779226974587,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Background:<\/jats:title>\n Inflammatory demyelinating diseases of the central nervous system represent a wide spectrum of entities and their classification cannot currently be regarded complete.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n Our aim is to describe a series of patients presenting with progressive myelopathy associated to a single demyelinating lesion of the spinal cord.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We identified the patients affected by chronic progressive spinal cord dysfunction related to a single spinal cord lesion not satisfying the diagnostic criteria for any of the currently defined diseases.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Seven females and one male were included. The median age at onset of symptoms was 53 years (range 42\u201368) and the median follow-up was 8 years (range 5\u201312). Brain and spinal magnetic resonance imaging (MRI) scans detected only one single, circumscribed, T2 hyperintense, non-longitudinally extensive lesion at level of cervico-medullary junction or cervical cord, in the absence of Gadolinium enhancement or swelling. Cerebrospinal fluid (CSF) examination displayed neither oligoclonal bands nor raised IgG index. A response to immunosuppressive agents was observed in some of the patients. Serial control brain and spinal MRI did not reveal accumulation of new lesions.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n New entities or variants should be included among the inflammatory demyelinating diseases of the central nervous system, and their characterization may have relevant prognostic and treatment implications.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1352458514535129","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T01:09:20Z","timestamp":1400807360000},"page":"1819-1824","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Multiple sclerosis, solitary sclerosis or something else?"],"prefix":"10.1177","volume":"20","author":[{"given":"Simona","family":"Lattanzi","sequence":"first","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Logullo","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Silvestrini","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Provinciali","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Marche Polytechnic University, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"bibr1-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0216-2"},{"key":"bibr2-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"bibr3-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.04.005"},{"key":"bibr4-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.499"},{"key":"bibr5-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"bibr6-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"key":"bibr7-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr8-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr9-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"bibr10-1352458514535129","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318247cc8c"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458514535129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458514535129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458514535129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:40:57Z","timestamp":1777693257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458514535129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":10,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1177\/1352458514535129"],"URL":"https:\/\/doi.org\/10.1177\/1352458514535129","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}