{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:18:53Z","timestamp":1777936733880,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Although cognitive dysfunction is a relevant aspect of multiple sclerosis (MS) from the earliest disease phase, cognitive onset is unusual thus jeopardizing early and accurate diagnosis. Here we describe 12 patients presenting with cognitive dysfunction as primary manifestation of MS with either mild or no impairment in non-cognitive neurological domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twelve patients with cognitive onset who were subsequently diagnosed with MS (CI-MS) were included in this retrospective study. Twelve cognitively normal MS patients (CN-MS), 12 healthy controls and four patients having progressive supranuclear palsy (PSP) served as the reference population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ten CI-MS patients had progressive clinical course and all patients had late disease onset (median age = 49 years; range = 40\u201358 years). Among cognitive functions, frontal domains were the most involved. Compared to CN-MS and healthy controls, significant cortical and infratentorial atrophy characterized CI-MS patients. Selective atrophy of midbrain tegmentum with relative sparing of pons, known as \u201cThe Hummingbird sign,\u201d was observed in eight CI-MS and in three PSP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Our observation suggests that MS diagnosis should be taken into consideration in case of cognitive dysfunction, particularly when associated with slowly progressive disease course and severe cortical, cerebellar and brainstem atrophy even in the absence of other major neurological symptoms and signs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458514542363","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T21:34:04Z","timestamp":1417210444000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Late-onset multiple sclerosis presenting with cognitive dysfunction and severe cortical\/infratentorial atrophy"],"prefix":"10.1177","volume":"21","author":[{"given":"Massimiliano","family":"Calabrese","sequence":"first","affiliation":[{"name":"Neurology Section, Department of Neurological and Movement Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Gajofatto","sequence":"additional","affiliation":[{"name":"Neurology Section, Department of Neurological and Movement Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Gobbin","sequence":"additional","affiliation":[{"name":"Neurology Section, Department of Neurological and Movement Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Turri","sequence":"additional","affiliation":[{"name":"Neurology Section, Department of Neurological and Movement 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