{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:17:57Z","timestamp":1779333477472,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>We report a patient with neuromyelitis optica (NMO) presenting anti-myelin-oligodendrocyte glycoprotein (MOG)-seropositive, in whom biomarkers of demyelination and astrocyte damage were measured during an acute attack. A 31-year-old man developed right optic neuritis followed by longitudinally extensive transverse myelitis, fulfilling the criteria for definite NMO. He was anti-MOG-seropositive and anti-aquaporin-4 seronegative. The myelin basic protein level was markedly elevated whereas glial fibrillary acidic protein was not detectable in cerebrospinal fluid during an acute attack. His symptoms quickly improved after high-dose methylprednisolone therapy. This case suggests that NMO patients with anti-MOG may have severe demyelination in the absence of astrocyte injury.<\/jats:p>","DOI":"10.1177\/1352458514551455","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T01:13:47Z","timestamp":1411694027000},"page":"656-659","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Severe demyelination but no astrocytopathy in clinically definite neuromyelitis optica with anti-myelin-oligodendrocyte glycoprotein antibody"],"prefix":"10.1177","volume":"21","author":[{"given":"Kensuke","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas Kazutoshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University School of Medicine, Sendai, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"bibr1-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"bibr2-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318296ea08"},{"key":"bibr3-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21837"},{"key":"bibr4-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1111\/j.1759-1961.2012.00030.x"},{"key":"bibr5-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e2414b"},{"key":"bibr6-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826aac4e"},{"key":"bibr7-1352458514551455","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"bibr8-1352458514551455","author":"Kitley J","year":"2014","journal-title":"JAMA 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