{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:35:36Z","timestamp":1787164536806,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In relapsing\u2013remitting multiple sclerosis (RRMS), the cerebellum is a known predilection site for atrophy. Neuromyelitis optica (NMO) is characterized by extensive lesions in the spinal cord and optic nerve; however, cerebellar involvement has been less studied. Secondary degeneration of the spinocerebellar tract could impact the cerebellum in NMO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate whether spinal cord and cerebellar volume measures differ between patients with NMO and RRMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Volumetric analyses of the cerebellum (TCV), the upper cervical cord (UCV) as well as the whole brain (NBV) of age- and gender-matched patients with NMO ( n=30; 56% AQP4 +ve) and RRMS ( n=25) were performed on 3T brain magnetic resonance imaging (MRI) and compared with 34 healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      UCV was significantly reduced in NMO patients (6.3 cm\n                      <jats:sup>3<\/jats:sup>\n                      ) as compared with HC (6.7 cm\n                      <jats:sup>3<\/jats:sup>\n                      ), while patients with MS had reduced brain volumes compared with HC (NBV=1482 cm\n                      <jats:sup>3<\/jats:sup>\n                      ; p&lt;0.001; TCV=188 cm\n                      <jats:sup>3<\/jats:sup>\n                      ; p=0.042), but UCV close to normal values. Patients with RRMS and NMO differed in NBV ( p=0.001; lower in RRMS) and by trend (towards reduction in RRMS) in cerebellar volume ( p=0.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>While atrophy seems to be diffuse in MS patients, a rather focussed pattern with predominant involvement of the UCV was observed in NMO patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458514554051","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T22:43:25Z","timestamp":1417819405000},"page":"757-766","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of cerebellar abnormalities in neuromyelitis optica \u2013 a comparison with multiple sclerosis and healthy controls"],"prefix":"10.1177","volume":"21","author":[{"given":"Katrin","family":"Weier","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Eshaghi","sequence":"additional","affiliation":[{"name":"MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Magon","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Andelova","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst-Wilhelm","family":"Radue","sequence":"additional","affiliation":[{"name":"Medical Image 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