{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:55:07Z","timestamp":1790358907167,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 \u00d7 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). Season of blood sampling (p = 2.8 \u00d7 10\n                      <jats:sup>\u221231<\/jats:sup>\n                      ), sex ( p = 1.9 \u00d7 10\n                      <jats:sup>\u22125<\/jats:sup>\n                      ), BMI ( p = 2.3 \u00d7 10\n                      <jats:sup>\u22125<\/jats:sup>\n                      ), vitamin supplements ( p = 7.0 \u00d7 10\n                      <jats:sup>\u221222<\/jats:sup>\n                      ), and fish intake ( p = 0.02) also had significant effects on 25(OH)D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458514563590","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T23:14:02Z","timestamp":1419290042000},"page":"1414-1422","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis"],"prefix":"10.1177","volume":"21","author":[{"given":"Julie H","family":"Laursen","sequence":"first","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Bach","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Albrechtsen","sequence":"additional","affiliation":[{"name":"Centre of Bioinformatics, Faculty of Science, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Frikke-Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Koch-Henriksen","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Treatment Register, Denmark\/Clinical Institute, Department of Clinical Epidemiology, University of Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Soelberg S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Sellebjerg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Oturai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, 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