{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:37:29Z","timestamp":1792006649136,"version":"4.4.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acquired demyelinating syndromes (ADS) in children are a group of distinct first immune-mediated demyelinating events of the central nervous system (CNS). Predictive biomarkers for future diagnosis are lacking. A putative target antigen is myelin oligodendrocyte glycoprotein (MOG). We analyzed the presence of MOG antibodies in a cohort of ADS patients in The Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using a cell-based assay, we analyzed 117 children with ADS from a nationwide cohort, whom were divided into five groups: optic neuritis (ON; n = 20), transverse myelitis (TM; n = 7), other monofocal ADS ( n = 22), polyfocal ADS without encephalopathy ( n = 44) and polyfocal ADS with encephalopathy ( n = 24). Additionally, we tested children with other neurological diseases (OND; n = 13), healthy children ( n = 31) and adult polyfocal ADS plus encephalopathy (ADEM) patients ( n = 29).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that 21 of the 117 children with ADS tested anti-MOG seropositive (18%). The group of patients with ADEM had the highest prevalence of anti-MOG seropositivity (42% versus 18% in the non-encephalopathic polyfocal ADS patients). Although 47 ADS children had a final diagnosis of multiple sclerosis (MS), in only one of them were MOG antibodies detected (2%), with only borderline positivity. Only 1 out of the 29 adult ADEM patients tested anti-MOG seropositive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MOG antibodies are strongly skewed towards ADS children that present with an ADEM-like disease onset. The presence of such antibodies pleads against a future diagnosis of MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458514566666","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T22:13:31Z","timestamp":1423260811000},"page":"1513-1520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":161,"title":["Anti-MOG antibodies plead against MS diagnosis in an Acquired Demyelinating Syndromes cohort"],"prefix":"10.1177","volume":"21","author":[{"given":"Immy A","family":"Ketelslegers","sequence":"first","affiliation":[{"name":"Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00eblle E","family":"Van Pelt","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Bryde","sequence":"additional","affiliation":[{"name":"Department Immunopathology, Sanquin Research, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinze F","family":"Neuteboom","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coriene E","family":"Catsman-Berrevoets","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rte","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Immunopathology and Blood Coagulation, Sanquin Diagnostic Services, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier Q","family":"Hintzen","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The 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