{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:03:33Z","timestamp":1780434213657,"version":"3.54.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The presence of anti-John Cunningham Virus (JCV) antibodies is a risk factor for the development of progressive multifocal leukoencephalopathy (PML) in MS patients treated with natalizumab. It has been suggested that an increase in serum anti-JCV antibody index precedes the development of PML. We here describe extensive longitudinal serum anti-JCV antibody indexes of four MS patients who developed PML. Anti-JCV antibodies were measured using the STRATIFY JCV\u2122DxSelect\u2122 test. All four patients had rather stable high anti-JCV antibody indexes in all samples obtained before developing PML. Possibly caused by reaching the saturation level of the assay, no increase in anti-JCV antibody indexes was seen just before the diagnosis of PML. This study confirms that high serum anti-JCV antibody indexes precede natalizumab-associated PML.<\/jats:p>","DOI":"10.1177\/1352458514567728","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T22:13:31Z","timestamp":1423260811000},"page":"1600-1603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Longitudinal JCV serology in multiple sclerosis patients preceding natalizumab-associated progressive multifocal leukoencephalopathy"],"prefix":"10.1177","volume":"21","author":[{"given":"Anke","family":"Vennegoor","sequence":"first","affiliation":[{"name":"Department of Neurology, MS Centre Amsterdam, VU Medical Centre, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannis A","family":"van Rossum","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre Amsterdam, VU Medical Centre, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris H","family":"Polman","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre Amsterdam, VU Medical Centre, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike P","family":"Wattjes","sequence":"additional","affiliation":[{"name":"Department of Radiology, MS Centre Amsterdam, VU Medical Centre, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep","family":"Killestein","sequence":"additional","affiliation":[{"name":"Department of Neurology, MS Centre Amsterdam, VU Medical Centre, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"bibr1-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"bibr2-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304332"},{"key":"bibr3-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513505353"},{"key":"bibr4-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182583022"},{"key":"bibr5-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24286"},{"key":"bibr6-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.02.002"},{"key":"bibr7-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7336-5"},{"key":"bibr8-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512467502"},{"key":"bibr9-1352458514567728","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22137"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458514567728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458514567728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458514567728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:43:10Z","timestamp":1777693390000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458514567728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1177\/1352458514567728"],"URL":"https:\/\/doi.org\/10.1177\/1352458514567728","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}