{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:14:23Z","timestamp":1784243663015,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>We report the case of a 46-year-old Japanese woman with neuromyelitis optica spectrum disorder presenting with repeated hypersomnia accompanied by decreased CSF orexin level. First episode associated with hypothalamic-pituitary dysfunction showed bilateral hypothalamic lesions that can cause secondary damage to the orexin neurons. The second episode associated with impaired memory showed a left temporal lesion involving the amygdala. The mechanism remains unknown, but the reduced blood flow in the hypothalamus ipsilateral to the amygdala lesion suggested trans-synaptic hypothalamic dysfunction secondary to the impaired amygdala. A temporal lesion involving the amygdala and hypothalamus could be responsible for hypersomnia due to neuromyelitis optica spectrum disorder.<\/jats:p>","DOI":"10.1177\/1352458515569100","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T22:34:13Z","timestamp":1423866853000},"page":"960-962","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Neuromyelitis optica spectrum disorder presenting with repeated hypersomnia due to involvement of the hypothalamus and hypothalamus-amygdala linkage"],"prefix":"10.1177","volume":"21","author":[{"given":"Kodai","family":"Kume","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurological Intractable Disease Research, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayuki","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kokudo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Neurological Intractable Disease Research, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Touge","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Kagawa University Faculty of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tohoku University Graduate School of Medicine, Japan; 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