{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:46:40Z","timestamp":1791226000524,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the clinical and magnetic resonance imaging (MRI) features of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-seropositive pediatric demyelinating syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Serum samples collected from 74 children with suspected demyelinating disorders whom were being followed at Massachusetts General Hospital were incubated with control green fluorescent protein (GFP)- and MOG-GFP-transfected Jurkat cell clones. The binding ratios were calculated using flow cytometry. Using statistical analyses, we compared the demographic, clinical and radiological features in our seropositive and seronegative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that 13 out of 74 (17.5%) patients were seropositive for MOG. The MOG-seropositive patients were younger than the seronegative patients ( p = 0.049). No single disease category predominated among the seropositive patients, nor was one group more likely to have a polyphasic course. There were two out of four neuromyelitis optica (NMO) patients who had MOG antibodies; both were seronegative for aquaporin \u22124 (AQP4) antibodies. One had monophasic disease and the other had frequent relapses. There was a bimodal distribution of the MOG-seropositive patients by age at onset, with a distinct younger group (4\u20138 years) having a high prevalence of encephalopathy and an older group (13\u201318 years), whom presented almost exclusively with optic neuritis. MRI analysis demonstrated the absence of corpus callosum lesions in the seropositive patients ( p = 0.012). The annualized relapse rate (ARR) and the Expanded Disability Status Scale (EDSS) results at 2 years did not differ between the seropositive and seronegative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MOG antibodies are found across a variety of pediatric demyelinating syndromes having some distinct clinical and MRI features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515587751","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T07:01:57Z","timestamp":1433401317000},"page":"174-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":129,"title":["Clinical and MRI phenotype of children with MOG antibodies"],"prefix":"10.1177","volume":"22","author":[{"given":"Cristina","family":"Fernandez-Carbonell","sequence":"first","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vargas-Lowy","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Musallam","sequence":"additional","affiliation":[{"name":"Partners MS Center, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Healy","sequence":"additional","affiliation":[{"name":"Partners MS Center, Brigham and Women\u2019s Hospital, Boston, MA, USA\/Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai W","family":"Wucherpfennig","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Boston, MA, USA\/Partners MS Center, Brigham and Women\u2019s Hospital, Boston, MA, USA\/Partners Pediatric MS Center, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"bibr1-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20890"},{"key":"bibr2-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011811-132443"},{"key":"bibr3-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1038\/nm1488"},{"key":"bibr4-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.11.013"},{"key":"bibr5-1352458515587751","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801888"},{"key":"bibr6-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2956"},{"key":"bibr7-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512470310"},{"key":"bibr8-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512466317"},{"key":"bibr9-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-184"},{"key":"bibr10-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"bibr11-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5857"},{"key":"bibr12-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826aac4e"},{"key":"bibr13-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259422.44235.a8"},{"key":"bibr14-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513484547"},{"key":"bibr15-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr16-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.505"},{"key":"bibr17-1352458515587751","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3216"},{"key":"bibr18-1352458515587751","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.581"},{"key":"bibr19-1352458515587751","unstructured":"Schwaiger F, Holzmann H. 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