{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:17:37Z","timestamp":1792581457958,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Retinal nerve fiber and ganglion cell+inner plexiform (GCIP) layer thinning following multiple sclerosis-related acute optic neuritis (AON) is well described. However, whether AON results in changes in the inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL) and\/or photoreceptor segment (PS) layers remains undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of this paper is to determine if INL+OPL and\/or ONL+PS changes occur following AON.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-three AON patients underwent serial optical coherence tomography (OCT) and visual function testing (mean follow-up: 25 months). Longitudinal changes in retinal layer thickness were analyzed using mixed-effects linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Four months following AON, the mean decrease in GCIP thickness relative to baseline was 11.4% ( p &lt; 0.001). At four months, a concomitant 3.4% increase in average ONL+PS thickness was observed ( p &lt; 0.001). The percentage decrease in GCIP thickness and increase in ONL+PS thickness were strongly correlated ( r = \u22120.70; p &lt; 0.001). Between months 4 to 12, ONL+PS thickness declined and, at 12 months, was no longer significantly different from baseline (mean change: 0.5%; p = 0.37). Similar, albeit less robust, changes in the INL+OPL were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Following AON, dynamic changes occur in the deep retinal layers, which are proportional to GCIP thinning. These novel findings help further our understanding of the biological and\/or anatomical sequelae resulting from AON.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515590646","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T22:45:21Z","timestamp":1437777921000},"page":"362-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Outer retinal changes following acute optic neuritis"],"prefix":"10.1177","volume":"22","author":[{"given":"Omar A","family":"Al-Louzi","sequence":"first","affiliation":[{"name":"Department of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins School of Medicine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins School of Medicine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D","family":"Newsome","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins School of Medicine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J","family":"Balcer","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University\u2014Langone Medical Center, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot M","family":"Frohman","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Ophthalmology, University of Texas Southwestern, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Crainiceanu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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