{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:20:12Z","timestamp":1790281212545,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate the frequency and clinical significance of antibodies to myelin oligodendrocyte glycoprotein (MOG-abs) in patients who presented with a first episode of seronegative aquaporin 4 antibody (AQP4-ab) longitudinally extensive transverse myelitis (LETM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Epidemiological, clinical, and paraclinical data of 56 patients from three European centres were analysed. Patients were retrospectively tested for MOG-abs and AQP4-abs, by cell-based assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>Thirteen (23.2%) patients were MOG-ab positive. Among the 56 patients, six (10.7%) converted to neuromyelitis optica (NMO), one (1.8%) to multiple sclerosis (MS), nine (16.1%) had recurrent LETM, and 40 (71.4%) remained as monophasic LETM. Compared with seronegative patients, those with MOG-abs were younger (median: 32.5 vs 44 years; p=0.007), had cerebrospinal fluid pleocytosis more frequently (94% vs 45%, p=0.003) and had better outcome (median Expanded Disability Status Scale (EDSS) 2.0 vs 3.0, p=0.027). MOG-ab positive patients also showed an increase risk of optic neuritis relapse and NMO conversion ( p=0.010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with MOG-abs in AQP4-ab seronegative LETM have clinical distinctive features, higher risk of optic neuritis relapses, and better outcome than patients seronegative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515591071","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T22:45:21Z","timestamp":1437777921000},"page":"312-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":75,"title":["Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications"],"prefix":"10.1177","volume":"22","author":[{"given":"\u00c1lvaro","family":"Cobo-Calvo","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Unit, Hospital Universitari de Bellvitge, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Center of Neuroimmunology, Service of Neurology, Hospital Cl\u00ednic and Institut d\u2032Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Bernard-Valnet","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU Toulouse, France\/Center for Pathophysiology of Toulouse Purpan, INSERM U1028\/CNRS 5282, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, INSERM U1028\/CNRS 5292, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brassat","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU Toulouse, France\/Center for Pathophysiology of Toulouse Purpan, INSERM U1028\/CNRS 5282, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Mart\u00ednez-Y\u00e9lamos","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit, Hospital Universitari de Bellvitge, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Saiz","sequence":"additional","affiliation":[{"name":"Center of Neuroimmunology, Service of Neurology, Hospital Cl\u00ednic and Institut d\u2032Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, INSERM U1028\/CNRS 5292, France\/Service de Neurologie A, H\u00f4pital Neurologique Pierre Wertheimer, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"bibr1-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr2-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.176"},{"key":"bibr3-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20770"},{"key":"bibr4-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514551454"},{"key":"bibr5-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3890"},{"key":"bibr6-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512451659"},{"key":"bibr7-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318296e917"},{"key":"bibr8-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011031014433"},{"key":"bibr9-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.118"},{"key":"bibr10-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.11.013"},{"key":"bibr11-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308346"},{"key":"bibr12-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512470310"},{"key":"bibr13-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2956"},{"key":"bibr14-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5857"},{"key":"bibr15-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514555785"},{"key":"bibr16-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"bibr17-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.8.671"},{"key":"bibr18-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.499"},{"key":"bibr19-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"bibr20-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr21-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.180"},{"key":"bibr22-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079083"},{"key":"bibr23-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318228c0b1"},{"key":"bibr24-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000040"},{"key":"bibr25-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-35"},{"key":"bibr26-1352458515591071","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514551455"}],"container-title":["Multiple 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