{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:32:46Z","timestamp":1790652766687,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T00:00:00Z","timestamp":1436486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to define radiological features of first-episode demyelinating ON.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON ( n=7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Bilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal involvement was more common in AQP4-ON (5% vs. 64% vs. 15%), and bilateral optic tract involvement was more common in AQP4-ON (0% vs. 45% vs. 0%). Retrobulbar involvement was more common in MOG-ON, whereas intracranial involvement was more common in AQP4-ON. MOG-ON and AQP4-ON had longer lesion lengths than MS-ON. The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. AQP4-ON more frequently had severe and sustained visual impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515593406","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T22:04:54Z","timestamp":1436565894000},"page":"470-482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":347,"title":["Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis"],"prefix":"10.1177","volume":"22","author":[{"given":"Sudarshini","family":"Ramanathan","sequence":"first","affiliation":[{"name":"Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children\u2019s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia\/Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Prelog","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, the Children\u2019s Hospital at Westmead, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H","family":"Barnes","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M","family":"Tantsis","sequence":"additional","affiliation":[{"name":"Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children\u2019s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W","family":"Reddel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia\/Brain and Mind Research Institute, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew PD","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia\/Department of Ophthalmology, Westmead Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Vucic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia\/Western Clinical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P","family":"Gorman","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A","family":"Benson","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital, Boston, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulay","family":"Alper","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J","family":"Riney","sequence":"additional","affiliation":[{"name":"Neurosciences Unit, Lady Cilento Children\u2019s Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Barnett","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Institute, University of Sydney, Sydney, Australia\/Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John DE","family":"Parratt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal North Shore Hospital, Central Clinical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A","family":"Hardy","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Institute, University of Sydney, Sydney, Australia\/Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Leventer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Melbourne Department of Paediatrics, Murdoch Children\u2019s Research Institute, The Royal Children\u2019s Hospital, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Merheb","sequence":"additional","affiliation":[{"name":"Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children\u2019s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Nosadini","sequence":"additional","affiliation":[{"name":"Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children\u2019s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor SC","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, 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