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We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS. Children displaying evidence of remote EBV without CMV infection were at highest risk of subsequent MS diagnosis. Viral infection repertoire detected at ADS provides important prognostic information.<\/jats:p>","DOI":"10.1177\/1352458515595876","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T21:31:00Z","timestamp":1437514260000},"page":"385-388","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination"],"prefix":"10.1177","volume":"22","author":[{"given":"Naila","family":"Makhani","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Neurology, Yale University School of Medicine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Banwell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Children\u2019s Hospital of Philadelphia and University of Pennsylvania, 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