{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:52:33Z","timestamp":1790783553130,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Spectral domain optical coherence tomography (SD-OCT) reveals retinal ganglion cell layer plus inner plexiform layer (GCL+IPL) and peripapillary retinal nerve fiber layer (pRNFL) thinning in chronic optic nerve injury. At presentation, swelling of the pRNFL confounds evaluation of early axon loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We studied whether the GCL+IPL thins before the pRNFL, the trajectory of GCL+IPL loss and relationship to vision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We prospectively evaluated 33 eyes (study) with new optic neuritis, using perimetry and SD-OCT with investigative three-dimensional layer segmentation and commercial two-dimensional segmentation to compute the GCL+IPL and pRNFL thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At presentation, GCL+IPL thickness (82.4\u00b18.8 \u00b5m) did not differ from unaffected fellow eyes (81.2\u00b16.7 \u00b5m), via the three-dimensional method, while the two-dimensional method failed in 9% of study eyes. At 1\u20132 months, there was thinning of the pRNFL in 10% and of the GCL+IPL in 93% of study eyes. GCL+IPL reduction was greatest during the first 2 months. GCL+IPL thinning at 1\u20132 months correlated with GCL+IPL thinning at 6 months ( r=0.84, P=0.01) and presentation visual acuity ( r=0.48, P=0.006) and perimetric mean deviation ( r=0.52, P=0.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1\u20132 months of onset, prior to pRNFL thinning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515598020","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T21:13:58Z","timestamp":1442006038000},"page":"641-648","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":90,"title":["Retinal ganglion cell layer thinning within one month of presentation for optic neuritis"],"prefix":"10.1177","volume":"22","author":[{"given":"Mark J","family":"Kupersmith","sequence":"first","affiliation":[{"name":"New York Eye and Ear Infirmary, Mount Sinai Roosevelt Hospital, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona K","family":"Garvin","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa, USA\/Department of Ophthalmology, Iowa University School of Medicine and Center for Prevention and Treatment of Visual Loss, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Durbin","sequence":"additional","affiliation":[{"name":"Carl Zeiss-Meditec, Inc., Dublin, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Kardon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Iowa University School of Medicine and Center for Prevention and Treatment of Visual Loss, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"bibr1-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.05.039"},{"key":"bibr2-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267272.60714.42"},{"key":"bibr3-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq146"},{"key":"bibr4-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.352"},{"key":"bibr5-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31820d7e9d"},{"key":"bibr6-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"bibr7-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20575"},{"key":"bibr8-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.12.1720"},{"key":"bibr9-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.05.042"},{"key":"bibr10-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.06.001"},{"key":"bibr11-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.09.045"},{"key":"bibr12-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0767-x"},{"key":"bibr13-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.014"},{"key":"bibr14-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10414"},{"key":"bibr15-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9401"},{"key":"bibr16-1352458515598020","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/aws150","volume":"135","author":"Fisher JB","year":"2012","journal-title":"Brain"},{"key":"bibr17-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.11.032"},{"key":"bibr18-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9300"},{"key":"bibr19-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000103"},{"key":"bibr20-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2008.923966"},{"key":"bibr21-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24351"},{"key":"bibr22-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9712"},{"key":"bibr23-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2011.11.002"},{"key":"bibr24-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10791"},{"key":"bibr25-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14961"},{"key":"bibr26-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0735"},{"key":"bibr27-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq080"},{"key":"bibr28-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513485149"},{"key":"bibr29-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9339"},{"key":"bibr30-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr264"},{"key":"bibr31-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf087"},{"key":"bibr32-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.175"},{"key":"bibr33-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260901"},{"key":"bibr34-1352458515598020","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e318238937f"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458515598020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458515598020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458515598020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:44:53Z","timestamp":1777693493000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458515598020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,11]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1177\/1352458515598020"],"URL":"https:\/\/doi.org\/10.1177\/1352458515598020","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,11]]}}}