{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:40:43Z","timestamp":1790628043850,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Optic neuritis is a good model for multiple sclerosis relapse, but currently no tests can accurately predict visual outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this study was to examine whether cerebrospinal fluid (CSF) biomarkers of tissue damage and remodelling (neurofilament light chain (NF-L), myelin basic protein, osteopontin and chitinase-3-like-1) predict visual outcome after optic neuritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included 47 patients with optic neuritis as a first demyelinating episode. Patients underwent visual tests, optical coherence tomography (OCT), magnetic resonance imaging (MRI) and lumbar puncture. Biomarkers were measured in CSF by enzyme-linked immunosorbent assay (ELISA). Patients were followed up six months after onset and this included visual tests and OCT. Outcome measures were inter-ocular differences in low contrast visual acuity (LCVA), retinal nerve fibre layer (RNFL) and ganglion cell layer+inner plexiform layer (GC-IPL) thicknesses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>CSF NF-L levels at onset predicted inter-ocular differences in follow-up LCVA (\u03b2=13.8, p=0.0008), RNFL (\u03b2=5.6, p=0.0004) and GC-IPL (\u03b2=4.0, p=0.0008). The acute-phase GC-IPL thickness also predicted follow-up LCVA (\u03b2=12.9, p=0.0021 for NF-L, \u03b2=\u22121.1, p=0.0150 for GC-IPL). Complete\/incomplete remission was determined based on LCVA from 30 healthy controls. NF-L had a positive predictive value of 91% and an area under the curve (AUC) of 0.79 for incomplete remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CSF NF-L is a promising biomarker of visual outcome after optic neuritis. This could aid neuroprotective\/regenerative medical advancements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515599074","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T20:59:48Z","timestamp":1439845188000},"page":"590-598","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Cerebrospinal fluid neurofilament light chain levels predict visual outcome after optic neuritis"],"prefix":"10.1177","volume":"22","author":[{"given":"S","family":"Modvig","sequence":"first","affiliation":[{"name":"The MS Clinic, Department of neurology, Glostrup Hospital, University of Copenhagen, Denmark\/Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Degn","sequence":"additional","affiliation":[{"name":"The MS Clinic, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark\/Department of Diagnostics, Glostrup Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Horwitz","sequence":"additional","affiliation":[{"name":"The MS Clinic, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark\/Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Wanscher","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Glostrup Hospital, University of Copenhagen, 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