{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:59:19Z","timestamp":1778770759475,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neuromyelitis optica (NMO)\u2013systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and anti-dsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses\/remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>AQP4-IgG1 was present 1\u20132\u20135 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and anti-nucleosome antibodies were elevated. Anti-MOG IgG\/IgM and AQP4-IgM antibodies were not detected. AQP4-IgG1 antibodies correlated with concentration of anti-nucleosome, IFN-\u03b3,interferon-gamma-induced CCL10\/IP-10 and CCL17\/TARC ( p&lt;0.05, respectively). CCL17\/TARC correlated with levels of anti-nucleosome and anti-dsDNA ( p&lt;0.05, respectively). Compared to healthy subjects, concentration of IFN-\u03b3 and CCL17\/TARC was higher in NMO\/SLE ( p&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>AQP4-IgG1 antibodies are present in the sera years before the first NMO attack in patients with SLE; elevation of anti-AQP4 is part of a polyclonal B cell response during NMO relapses; in spite of multiple autoantibodies in the serum, MOG antibodies were not present; Th1 responses accompany autoantibody responses in NMO\/SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458515613165","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T23:38:15Z","timestamp":1446161895000},"page":"1192-1201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study"],"prefix":"10.1177","volume":"22","author":[{"given":"Katalin T","family":"Kovacs","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, University of Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhakar Reddy","family":"Kalluri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Boza-Serrano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Deierborg","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tunde","family":"Csepany","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdolna","family":"Simo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Semmelweis University, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Rokusz","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Military Hospital \u2013 State Health Centre, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Miseta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Alcaraz","sequence":"additional","affiliation":[{"name":"Computational Biology Group, Department of Mathematics and Computer Science (IMADA), University of Southern Denmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Czirjak","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, University of Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timea","family":"Berki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tihamer","family":"Molnar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Germany\/Munich Cluster for Systems Neurology (SyNergy), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Illes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Odense University Hospital, Denmark\/Institute of Clinical Research, University of Southern Denmark, 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