{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:17Z","timestamp":1787019137487,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Available data suggest that pregnancy exposure to interferon-beta might result in lower mean birth weight and preterm birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the effect of interferon-beta exposure during pregnancy on pregnancy outcomes in multiple sclerosis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We compared the pregnancy outcomes of women exposed to interferon-beta with pregnancies unexposed to disease-modifying therapies. Women were enrolled into the German Multiple Sclerosis and Pregnancy Registry. A standardized questionnaire was administered during pregnancy and postpartum. Detailed information on course of multiple sclerosis and pregnancy, concomitant medications, delivery, and outcome of pregnancy was obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We collected data on 251 pregnancies exposed to interferon-beta and 194 unexposed to disease-modifying therapies. In all, 246 (98.01%) women discontinued interferon-beta treatment during first trimester. No differences regarding mean birth weight (exposed: 3272.28\u2009\u00b1\u2009563.61 g; unexposed: 3267.46\u2009\u00b1\u2009609.81\u2009g), mean birth length (exposed: 50.73\u2009\u00b1\u20093.30\u2009cm; unexposed: 50.88\u2009\u00b1\u20093.45\u2009cm), preterm birth ( p\u2009=\u20090.187), spontaneous abortion ( p\u2009=\u20090.304), and congenital anomalies ( p\u2009=\u20090.197) were observed between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Interferon-beta exposure during early pregnancy does not influence the mean birth weight, risk of preterm birth, or other adverse pregnancy outcomes. Our study provides further reassurance that interferon-beta treatment can be safely continued up until women become pregnant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516634872","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T22:19:09Z","timestamp":1456525149000},"page":"801-809","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":102,"title":["Interferon-beta exposure during first trimester is safe in women with multiple sclerosis\u2014A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry"],"prefix":"10.1177","volume":"22","author":[{"given":"Sandra","family":"Thiel","sequence":"first","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany\/Institute of Clinical Pharmacy and Pharmacotherapy, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Langer-Gould","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California, Pasadena, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Rockhoff","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University, Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"Haghikia","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University, Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Queisser-Wahrendorf","sequence":"additional","affiliation":[{"name":"Centre of Paediatrics and Youth Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University, Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef Hospital, Ruhr University, Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"bibr1-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70581-6"},{"key":"bibr2-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237641.33768.8d"},{"key":"bibr3-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004536"},{"key":"bibr4-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.04.024"},{"key":"bibr5-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182698c64"},{"key":"bibr6-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612453192"},{"key":"bibr7-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511422244"},{"key":"bibr8-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5758-2"},{"key":"bibr9-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.11.016"},{"key":"bibr10-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510394610"},{"key":"bibr11-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5376-z"},{"key":"bibr12-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fd62bb"},{"key":"bibr13-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2009000400015"},{"key":"bibr14-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509102366"},{"key":"bibr15-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509106543"},{"key":"bibr16-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0909-4"},{"key":"bibr17-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507077896"},{"key":"bibr18-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168905.97207.d0"},{"key":"bibr19-1352458516634872","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180575.77021.c4"},{"key":"bibr20-1352458516634872","unstructured":"Biogen Idec Inc. 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