{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:21:24Z","timestamp":1777936884752,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D sufficiency is associated with better inflammatory outcomes in multiple sclerosis (MS). We hypothesize that it is also associated with better long-term neurodegenerative measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To show that vitamin D sufficient patients (25-hydroxy vitamin D (25(OH)D)\u2009&gt;\u200980\u2009nmol\/L) have better optical coherence tomography (OCT) neuroaxonal measures of ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thickness after optic neuritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective cohort study, acute optic neuritis patients underwent OCT and serum 25(OH)D assessments at baseline and at month 6, with comparisons between vitamin D sufficient and insufficient patients, and men and women. Potential confounding variables were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 49 enrolled, 36 had complete, analyzable data. At baseline, vitamin D insufficiency was associated with greater RNFL thickness (134.3 vs. 95.2\u2009\u00b5m; p\u2009=\u20090.003) in affected eyes. At month 6, insufficient patients had greater GCL thinning (GCL inter-eye difference: 14.2 vs. 4.0\u2009\u00b5m, p\u2009=\u20090.008). Men had greater RNFL and GCL thinning than women (GCL: 61.2 vs. 69.6\u2009\u00b5m, p\u2009=\u20090.036).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acutely, in optic neuritis, RNFL thickness is increased with vitamin D insufficiency. Chronically, neuronal, and possibly axonal loss are associated with vitamin D insufficiency and male gender, suggesting vitamin D and female gender may confer neuroprotection in optic neuritis, and possibly, central nervous system (CNS) inflammatory disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516642315","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T22:53:06Z","timestamp":1459551186000},"page":"82-93","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["A prospective cohort study of vitamin D in optic neuritis recovery"],"prefix":"10.1177","volume":"23","author":[{"given":"Jodie M","family":"Burton","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Department of Community Health Sciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misha","family":"Eliasziw","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie","family":"Trufyn","sequence":"additional","affiliation":[{"name":"Neurosciences Graduate Program, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsia","family":"Tung","sequence":"additional","affiliation":[{"name":"Biological Sciences Undergraduate Sciences Program, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorden","family":"Carter","sequence":"additional","affiliation":[{"name":"Eye Clinic, Rockyview General Hospital, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Department of Surgery (Ophthalmology), Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1960.tb08674.x"},{"key":"bibr2-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1159\/000054783"},{"key":"bibr3-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7410.316"},{"key":"bibr4-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000268266.50850.48"},{"key":"bibr5-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2832"},{"key":"bibr6-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1191\/1352458505ms1157oa"},{"key":"bibr7-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508094399"},{"issue":"2","key":"bibr8-1352458516642315","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.22043","volume":"68","author":"Simpson S","year":"2010","journal-title":"Ann Neurol"},{"key":"bibr9-1352458516642315","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ana.21972","volume":"67","author":"Mowry EM","year":"2010","journal-title":"Ann Neurol"},{"key":"bibr10-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23591"},{"key":"bibr11-1352458516642315","unstructured":"ClinicalTrials.gov Identifier: NCT01285401. Supplementation of VigantOL\n                      \u00ae\n                      oil versus placebo as add-on in patients with relapsing remitting multiple sclerosis receiving Rebif\n                      \u00ae\n                      Treatment (SOLAR)."},{"key":"bibr12-1352458516642315","unstructured":"ClinicalTrials.gov Identifier: NCT01490502. Vitamin D in multiple sclerosis."},{"key":"bibr13-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/134858"},{"key":"bibr14-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70095-8"},{"key":"bibr15-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0950"},{"key":"bibr16-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-010-0005-1"},{"key":"bibr17-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508091367"},{"key":"bibr18-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq146"},{"key":"bibr19-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr264"},{"key":"bibr20-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070172"},{"key":"bibr21-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318271f755"},{"key":"bibr22-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000524"},{"key":"bibr23-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr24-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"bibr25-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"bibr26-1352458516642315","first-page":"289785","volume":"2011","author":"Costello F","year":"2011","journal-title":"Mult Scler Int"},{"key":"bibr27-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70168-X"},{"key":"bibr28-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71003-X"},{"issue":"7","key":"bibr29-1352458516642315","first-page":"738","volume":"69","author":"Kalueff AV","year":"2004","journal-title":"Biochemistry"},{"key":"bibr30-1352458516642315","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.158266"},{"key":"bibr31-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7740-5"},{"key":"bibr32-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14993"},{"key":"bibr33-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1177\/1756285613488434"},{"key":"bibr34-1352458516642315","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3710"},{"key":"bibr35-1352458516642315","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.4119"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516642315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458516642315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516642315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:46:52Z","timestamp":1777693612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458516642315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/1352458516642315"],"URL":"https:\/\/doi.org\/10.1177\/1352458516642315","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}