{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:58:05Z","timestamp":1783763885573,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The international panel for neuromyelitis optica (NMO) diagnosis has proposed diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We assessed the impact of these criteria on diagnostic rates in a large cohort of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We identified and applied the 2006 and 2015 criteria to all patients ( n\u2009=\u2009176) seen in the NMO and non-multiple sclerosis central nervous system demyelination clinic (part of the UK NMO service) from January 2013 to May 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The 2006 criteria classified 63 of 176 (36%) patients as NMO. A total of 42 patients (67%) were aquaporin 4 (AQP4) immunoglobulin G (IgG) +ve and 21 (33%) AQP4 IgG \u2212ve. The 2015 criteria classified 111 of 176 (63%) patients as NMOSD, of which 81 (73%) were AQP4 IgG +ve and 30 (27%) were AQP4 IgG \u2212ve. There was an increase of 48 patients (76%) diagnosed as NMOSD using the new criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Application of the 2015 criteria led to a rise in diagnosis of NMOSD by 76%. The rise in the AQP4 IgG +ve group contributed 62% and the seronegative group contributed 14%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516663853","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T21:58:40Z","timestamp":1471989520000},"page":"228-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates"],"prefix":"10.1177","volume":"23","author":[{"given":"Shahd HM","family":"Hamid","sequence":"first","affiliation":[{"name":"The Walton Centre, NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liene","family":"Elsone","sequence":"additional","affiliation":[{"name":"The Walton Centre, NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Mutch","sequence":"additional","affiliation":[{"name":"The Walton Centre, NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Solomon","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Global Health, University of Liverpool, Liverpool, UK\/The Walton Centre, NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Jacob","sequence":"additional","affiliation":[{"name":"The Walton Centre, NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"bibr1-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6646-8"},{"key":"bibr2-1352458516663853","first-page":"1033","volume":"8","author":"Devic E","year":"1894","journal-title":"Bull Med"},{"key":"bibr3-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36534"},{"key":"bibr4-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"bibr5-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"bibr6-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"bibr7-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"bibr8-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318296ea08"},{"key":"bibr9-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0256-1"},{"key":"bibr10-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr11-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318248dec1"},{"key":"bibr12-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7952-8"},{"key":"bibr13-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000060"},{"key":"bibr14-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000062"},{"key":"bibr15-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2012-000237"},{"key":"bibr16-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002655"},{"key":"bibr17-1352458516663853","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2012.06.002"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516663853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458516663853","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516663853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:47:54Z","timestamp":1777693674000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458516663853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/1352458516663853"],"URL":"https:\/\/doi.org\/10.1177\/1352458516663853","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}