{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:48:28Z","timestamp":1789674508031,"version":"4.0.1"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Reported cases\/outcomes:<\/jats:title>\n                    <jats:p>While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5\u2009months after Patient 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516670734","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T18:57:04Z","timestamp":1486407424000},"page":"300-303","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence"],"prefix":"10.1177","volume":"23","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Bacchetta","sequence":"first","affiliation":[{"name":"Laboratory of Neuroimmunology, Service of Neurology, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Mathias","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimmunology, Service of Neurology, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Schluep","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimmunology, Service of Neurology, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Du Pasquier","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimmunology, Service of Neurology, Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"bibr1-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70040-5"},{"key":"bibr2-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-32957-9_2"},{"key":"bibr3-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22128"},{"key":"bibr4-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-164018"},{"key":"bibr5-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512466165"},{"key":"bibr6-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir507"},{"key":"bibr7-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1080\/13550280152537210"},{"key":"bibr8-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.07.016"},{"key":"bibr9-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.12.5672-5676.2001"},{"key":"bibr10-1352458516670734","doi-asserted-by":"publisher","DOI":"10.3109\/13550289609146907"},{"key":"bibr11-1352458516670734","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh215"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516670734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458516670734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516670734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:48:14Z","timestamp":1777693694000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458516670734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/1352458516670734"],"URL":"https:\/\/doi.org\/10.1177\/1352458516670734","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}