{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:03:55Z","timestamp":1778087035244,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korea Health Industry Development Institute Research fund","award":["A121118"],"award-info":[{"award-number":["A121118"]}]},{"name":"SNUBH Research Fund","award":["02-2015-029"],"award-info":[{"award-number":["02-2015-029"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G (NMOSD-AQP4) is an inflammatory disease characterised by a high female predominance. However, the effect of gender in patients with NMOSD-AQP4 has not been fully evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to determine the effect of gender in clinical manifestations and prognosis of patients with NMOSD-AQP4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The demographics, clinical and radiological characteristics, pattern reversal visual evoked potential (VEP) test results, and prognosis of 102 patients (18 males) with NMOSD-AQP4 were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Male patients had a higher age at onset (48.7 vs 41\u2009years, p\u2009=\u20090.037) and less optic neuritis as the onset attack (17% vs 44%, p\u2009=\u20090.026), higher tendency to manifest as isolated myelitis over the follow-up period (67% vs 28%, p\u2009=\u20090.005), fewer optic neuritis attacks per year (0.08 vs 0.27, p\u2009&lt;\u20090.001), and shorter relative P100 latency on VEP testing (97.1% vs 108.3%, p\u2009=\u20090.001). Moreover, male gender was significantly associated with the absence of optic neuritis attacks over the follow-up period independent of their age of onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In NMOSD-AQP4 patients, gender impacts on disease onset age and site of attack. This may be an important clue in identifying NMOSD-AQP4 patients with limited manifestations as well as in predicting their clinical courses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516674366","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T22:54:28Z","timestamp":1476917668000},"page":"1104-1111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G"],"prefix":"10.1177","volume":"23","author":[{"given":"Sung-Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Waters","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Neuroimmunology Group, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Woodhall","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Neuroimmunology Group, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Young","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University, Bundang Hospital, Seongnam, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Rae","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University, Bundang Hospital, Seongnam, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University, Bundang Hospital, Seongnam, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong Cheon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University College of Medicine, Seoul, 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