{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:10:05Z","timestamp":1784675405031,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effectiveness and tolerance of mycophenolate mofetil (MMF) as a first-line treatment in neuromyelitis optica spectrum disorder (NMOSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In all, 67 NMOSD patients treated by MMF as first-line therapy, from the NOMADMUS cohort were included. A total of 65 fulfilled 2015 NMOSD criteria, and 5 were myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) positive. Effectiveness was evaluated on percentage of patients continuing MMF, percentage of patients free of relapse, pre- and post-treatment change in the annualized relapse rate (ARR), and Expanded Disability Status Scale (EDSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 67 patients, 40 (59.7%) continued treatment till last follow-up. A total of 33 (49.3%) were relapse-free. The median ARR decreased from one pre-treatment to zero post-treatment. Of 53 patients with complete EDSS data, the score improved or stabilized in 44 (83%; p\u2009&lt;\u20090.05). Effectiveness was observed in aquaporin-4 (AQP4)-IgG (57.8% continued treatment, 46.7% relapse-free), MOG-IgG (3\/5 continued treatment, 4\/5 relapse-free), and seronegative NMOSD (64.7% continued treatment, 61.3% relapse-free). In 16 patients with associated steroids, 13 (81.2%) continued MMF till last follow-up versus 15 of 28 (53.6%) in the non-steroid group. Nine patients discontinued treatment for tolerability purpose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MMF showed effectiveness and good tolerability as a first-line therapy in NMOSD, whatever the AQP4-IgG status. Concomitant use of oral steroids at start could limit the risk of treatment failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516678474","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T22:00:14Z","timestamp":1480024814000},"page":"1377-1384","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":104,"title":["Effectiveness of mycophenolate mofetil as first-line therapy in AQP4-IgG, MOG-IgG, and seronegative neuromyelitis optica spectrum disorders"],"prefix":"10.1177","volume":"23","author":[{"given":"Alexis","family":"Montcuquet","sequence":"first","affiliation":[{"name":"Service de Neurologie A and Eug\u00e8ne Devic EDMUS Foundation against Multiple Sclerosis, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques (OFSEP), H\u00f4pital Neurologique Pierre Wertheimer\u2014GHE, Hospices Civils de Lyon, Bron, France\/Department of Neurology, H\u00f4pital Dupuytren, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Collongues","sequence":"additional","affiliation":[{"name":"Department of Neurology, and INSERM CIC-1434, CHU de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Papeix","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Zephir","sequence":"additional","affiliation":[{"name":"Clinique Neurologique, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Audoin","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Timone, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Laplaud","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Bourre","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Brochet","sequence":"additional","affiliation":[{"name":"Department of Neurology, and INSERM-CHU CIC-P 0005, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Camdessanche","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Labauge","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Moreau","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brassat","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Stankoff","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hopital Tenon, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"de Seze","sequence":"additional","affiliation":[{"name":"Department of Neurology and INSERM CIC-1434, CHU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Service de Neurologie A and Eug\u00e8ne Devic EDMUS Foundation against Multiple Sclerosis, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques (OFSEP), H\u00f4pital Neurologique Pierre Wertheimer\u2014GHE, Hospices Civils de Lyon, Bron, France\/Lyon\u2019s Neuroscience Research Center, Team ONCOFLAM, Inserm U 1028\/CNRS 5292, Lyon, France Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Service de Neurologie A and Eug\u00e8ne Devic EDMUS Foundation against Multiple Sclerosis, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques (OFSEP), H\u00f4pital Neurologique Pierre Wertheimer\u2014GHE, Hospices Civils de Lyon, Bron, France\/Lyon\u2019s Neuroscience Research Center, Team ONCOFLAM, Inserm U 1028\/CNRS 5292, Lyon, France Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of NOMADMUS study group and the Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques 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