{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:22:36Z","timestamp":1777936956743,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fingolimod is a widely used treatment for highly active relapsing\u2013remitting multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To describe the case of a 27-year-old patient treated for more than 2\u2009years by Fingolimod, who presented hemiplegia and speech disturbances associated with extensive white matter lesions on brain magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Case study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Although initial presentation questioned the possibility of progressive multifocal leukoencephalopathy, final diagnosis was multiple sclerosis (MS) relapse. Appropriate treatment resulted in clinical and radiological improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Severe MS relapses under Fingolimod have been reported, but late onset after treatment initiation and extensive subcortical topography is unusual and represents a diagnostic challenge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516682858","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T06:19:06Z","timestamp":1484806746000},"page":"614-616","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Extensive white matter lesions after 2\u2009years of fingolimod: Progressive multifocal leukoencephalopathy or MS relapse?"],"prefix":"10.1177","volume":"23","author":[{"given":"Marine","family":"Boudot de la Motte","sequence":"first","affiliation":[{"name":"Neurology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Louapre","sequence":"additional","affiliation":[{"name":"Neurology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Diagnostic and Functional Neuroradiology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France\/Inserm U1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM, Inria Paris-Rocquencourt, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Reach","sequence":"additional","affiliation":[{"name":"Neurology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lubetzki","sequence":"additional","affiliation":[{"name":"Neurology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Papeix","sequence":"additional","affiliation":[{"name":"Neurology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Maillart","sequence":"additional","affiliation":[{"name":"Neurology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, APHP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"bibr1-1352458516682858","first-page":"261","volume":"12","author":"Ayzenberg 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