{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:50:59Z","timestamp":1790650259573,"version":"4.1.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC-TR-128"],"award-info":[{"award-number":["CRC-TR-128"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516683267","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T06:47:57Z","timestamp":1492498077000},"page":"1167-1169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["A \u201ckissing lesion\u201d: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis"],"prefix":"10.1177","volume":"23","author":[{"given":"Pierre","family":"Kolber","sequence":"first","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amgad","family":"Droby","sequence":"additional","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alard","family":"Roebroeck","sequence":"additional","affiliation":[{"name":"Maastricht Brain Imaging Center, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Goebel","sequence":"additional","affiliation":[{"name":"Maastricht Brain Imaging Center, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinzenz","family":"Fleischer","sequence":"additional","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiu","family":"Groppa","sequence":"additional","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Zipp","sequence":"additional","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"bibr1-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.09.021"},{"key":"bibr2-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3900"},{"key":"bibr3-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm038"},{"key":"bibr4-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100648"},{"key":"bibr5-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww037"},{"key":"bibr6-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.002"},{"key":"bibr7-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31824600e9"},{"key":"bibr8-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23959"},{"key":"bibr9-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001586"},{"key":"bibr10-1352458516683267","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.02.001"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516683267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458516683267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458516683267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:49:03Z","timestamp":1777693743000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458516683267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/1352458516683267"],"URL":"https:\/\/doi.org\/10.1177\/1352458516683267","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]}}}