{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:38Z","timestamp":1791229478880,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to describe the characteristic features of patients with LO-NMOSD in Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (\u2a7e50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (&lt;50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among a total of 147 patients (125 female; age of onset, 39.4 \u00b1 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LO-NMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up ( r = 0.246, p = 0.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1352458516685416","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T11:12:37Z","timestamp":1483787557000},"page":"1748-1756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":79,"title":["Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea"],"prefix":"10.1177","volume":"23","author":[{"given":"Jin Myoung","family":"Seok","sequence":"first","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea\/Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bucheon St. Mary\u2019s Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk-Won","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Su","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Soo","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ajou University College of Medicine, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Kuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Dong-A University, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong-Yang","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Kosin University, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Eulji University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea\/Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea\/Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea\/Neuroscience Center, Samsung Medical Center, Seoul, 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