{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:31Z","timestamp":1790775751629,"version":"4.1.0"},"reference-count":7,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>We report the case of a 42-year-old female patient who developed peculiar skin lesions due to subcutaneous polyethylene glycol (PEG) interferon beta-1a. The dermatological examination showed hypochromic macules that had coalesced into a 10-cm-diameter patch. On the abdomen injection sites, there was a greyish diffuse hyperpigmentation arranged irregularly in annular macules. Fungal infection, vitiligo and pityriasis alba were excluded. After 6 months, the lesions had worsened. This is the first case of localized pigmentation disorder reported with interferon beta, and while the clinical findings are not ascribable to vitiligo or interferon-related facial\/mucosal hyperpigmentation, they may partially share the underlining mechanisms.<\/jats:p>","DOI":"10.1177\/1352458517708465","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T05:34:52Z","timestamp":1501220092000},"page":"231-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Localized pigmentation disorder after subcutaneous pegylated interferon beta-1a injection"],"prefix":"10.1177","volume":"24","author":[{"given":"Giancarlo","family":"Coghe","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Atzori","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Frau","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fenu","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Lorefice","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Marrosu","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Cocco","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"bibr1-1352458517708465","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S69123"},{"key":"bibr2-1352458517708465","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(03)00108-X"},{"key":"bibr3-1352458517708465","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04088.x"},{"key":"bibr4-1352458517708465","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.42"},{"key":"bibr5-1352458517708465","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1989"},{"key":"bibr6-1352458517708465","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02563.x"},{"issue":"6","key":"bibr7-1352458517708465","first-page":"515","volume":"27","author":"Grimes PE","year":"2001","journal-title":"Dermatol Surg"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458517708465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1352458517708465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1352458517708465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:50:43Z","timestamp":1777693843000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1352458517708465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1177\/1352458517708465"],"URL":"https:\/\/doi.org\/10.1177\/1352458517708465","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}