{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:10:04Z","timestamp":1784675404301,"version":"3.55.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15\/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n\u2009=\u20098), hyperinsulinaemia ( n\u2009=\u20095), hyperandrogenism ( n\u2009=\u20095), amenorrhoea ( n\u2009=\u20095), hyponatraemia ( n\u2009=\u20094), short stature ( n\u2009=\u20093) and central hypothyroidism ( n\u2009=\u20092) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7\/8) of children of Caribbean origin. As endocrinopathies were prevalent in the majority of paediatric-onset AQP4-Ab NMOSD, endocrine surveillance and in particular early aggressive weight management is required for patients with AQP4-Ab NMOSD.<\/jats:p>","DOI":"10.1177\/1352458517726593","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T04:06:03Z","timestamp":1502683563000},"page":"679-684","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody"],"prefix":"10.1177","volume":"24","author":[{"given":"Yael","family":"Hacohen","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology, Great Ormond Street Hospital for Children, London, UK\/Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK\/Department of Neurosciences, Great Ormond Street Hospital for Children, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Messina","sequence":"additional","affiliation":[{"name":"Neurology Department, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoong-Wei","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Great Ormond Street Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhvir","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology, Birmingham Children\u2019s Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleel","family":"Chandratre","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology, John Radcliffe Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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